{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:37:56Z","timestamp":1777473476522,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T00:00:00Z","timestamp":1461369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Council grant","award":["103-2314-B-182A-056-MY2"],"award-info":[{"award-number":["103-2314-B-182A-056-MY2"]}]},{"name":"Chang Gung Medical Foundation grant","award":["CMRPG 3D1412"],"award-info":[{"award-number":["CMRPG 3D1412"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Direct suspension laryngoscopic biopsy performed under general anesthesia is the conventional management for obtaining pathological diagnosis for neoplasms of the larynx, oropharynx, and hypopharynx. Since the development of distal chip laryngoscopy and digital imaging systems, transnasal flexible laryngoscopy tissue sampling has gained popularity as an office\u2010based procedure. Additional assessment with narrow\u2010band imaging (NBI) can help to increase the diagnostic yield. The aim of the study was to evaluate the accuracy, sensitivity, and specificity of a novel diagnostic tool: office\u2010based NBI (OB\u2010NBI) flexible laryngoscopic tissue sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review performed in a tertiary referral medical center in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2010 to February 2013, 90 consecutive patients received OB\u2010NBI biopsies. The accuracies of the OB\u2010NBI biopsies were compared among locations, tumor sizes, head and neck cancer histories, and other factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had completed the procedure without life\u2010threatening complications. The overall sensitivity and specificity were 97.2% and 100%, respectively, with a diagnostic accuracy of 98.9%. Accuracy was not affected by tumor size, location, learning curves, or previous head and neck cancer history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present an integrated technique that merges the safety and versatility of flexible laryngoscopy with the diagnostic power of NBI to produce a promising method of high accuracy and minimal morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 126:2764\u20132769, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26016","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T14:29:19Z","timestamp":1461421759000},"page":"2764-2769","source":"Crossref","is-referenced-by-count":17,"title":["Reliability of office\u2010based narrow\u2010band imaging\u2013guided flexible laryngoscopic tissue samplings"],"prefix":"10.1002","volume":"126","author":[{"given":"Catherine","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Hand and Neck Surgery Chang Gung Memorial Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010Ni","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Hand and Neck Surgery Chang Gung Memorial Hospital Taipei Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Jen","family":"Hsin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Hand and Neck Surgery Chang Gung Memorial Hospital Taipei Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Ang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Hand and Neck Surgery Chang Gung Memorial Hospital Taipei Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chang Gung Memorial Hospital Linkou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Hand and Neck Surgery Chang Gung Memorial Hospital Taipei Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Hand and Neck Surgery Chang Gung Memorial Hospital Taipei Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan\u2010Jen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Hand and Neck Surgery Chang Gung Memorial Hospital Taipei Taiwan"},{"name":"School of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.38"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10145"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1695563"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2010.12.001"},{"key":"e_1_2_7_6_1","first-page":"41","article-title":"Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification","volume":"28","author":"Inoue H","year":"2015","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20482"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4680"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.12.034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-1989-4"},{"key":"e_1_2_7_11_1","first-page":"49","article-title":"Narrow\u2010band imaging: a new tool for evaluation of head and neck squamous cell carcinomas. 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