{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:17:57Z","timestamp":1775672277801,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T00:00:00Z","timestamp":1461369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Heart and Lung Foundation"},{"name":"Acta Otolaryngologica Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Objectives\/Hypothesis<\/jats:title>To study whether tonsillectomy is effective on obstructive sleep apnea (OSA) in adults with large tonsils.<\/jats:p><\/jats:sec>Study Design<\/jats:title>A multicenter prospective interventional study.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study comprised 28 patients with OSA, an apnea\u2013hypopnea index of > 10, large tonsils (Friedman tonsil size 3 and 4), and age 18 to 59 years. They were derived from 41 consecutive males and females with large tonsils referred for a suspicion of sleep apnea to the ear, nose, and throat departments in Ume\u00e5, Skellefte\u00e5, and Sunderbyn in northern Sweden. The primary outcome was the apnea\u2013hypopnea index, measured with polygraphic sleep apnea recordings 6 months after surgery. Secondary outcomes included daytime sleepiness, as measured with the Epworth Sleepiness Scale, and swallowing function, using video\u2010fluoroscopy.<\/jats:p><\/jats:sec>Results<\/jats:title>The apnea\u2013hypopnea index was reduced from a mean of 40 units per hour (95% confidence interval [CI] 28\u201351) to seven units per hour (95% CI 3\u201311), P<\/jats:italic> < 0.001, at the 6\u2010month follow\u2010up after surgery. The apnea\u2013hypopnea index was reduced in all patients and 18 (64%) were cured. The Epworth Sleepiness Scale was reduced from a mean of 11 (95% CI 8\u201313) to 6.0 (95% CI 4\u20137), P<\/jats:italic> < 0.001. A swallowing dysfunction was found in seven of eight investigated patients before surgery. Of those, swallowing function improved in five patients after surgery, whereas no one deteriorated.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Tonsillectomy may be effective treatment for adult patients with OSA and large tonsils. Tonsillectomy may be suggested for adults with OSA and large tonsils.<\/jats:p><\/jats:sec>Level of Evidence<\/jats:title>4. Laryngoscope<\/jats:italic>, 126:2859\u20132862, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26038","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T14:29:02Z","timestamp":1461421742000},"page":"2859-2862","source":"Crossref","is-referenced-by-count":33,"title":["Tonsillectomy in adults with obstructive sleep apnea"],"prefix":"10.1002","volume":"126","author":[{"given":"Thorbj\u00f6rn","family":"Holmlund","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences\/Otorhinolaryngology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl A.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences\/Surgery Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Levring J\u00e4ghagen","sequence":"additional","affiliation":[{"name":"Department of Odontology\/Oral and Maxillofacial Radiology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Lindkvist","sequence":"additional","affiliation":[{"name":"Department of Ume\u00e5 School of Business and Economics\/Statistics Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Department of Public Health and Clinical Medicine\/Epidemiology and Global Health Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f6rn","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/Otorhinolaryngology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carin","family":"Sahlin","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine\/Medicine Ume\u00e5 University Ume\u00e5 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