{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:01:33Z","timestamp":1770444093318,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To investigate the utility of a brain magnetic resonance imaging (MRI) in children with sleep\u2010disordered breathing (SDB), classified as isolated obstructive sleep apnea (OSA) in the absence of adenotonsillar hypertrophy, persistent OSA following adenotonsillectomy, isolated central sleep apnea (CSA) of unclear etiology, OSA with coexisting CSA of unclear etiology, or unexplained nocturnal hypoventilation (NH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review of polysomnography (PSG) and brain MRI data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with PSG evidence of SDB, as described above, and who subsequently had their first brain MRI, were included. PSG, MRI data, and subsequent interventions were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 59 of 6,087 (1%) children met inclusion criteria. Of those, 28 of 59 (47%) were nonsyndromic children and 31 of 59 (53%) were syndromic children with an underlying medical disorder. Abnormal brain MRI findings were observed in 19 of 59 (32%) children, where eight of 19 (42%) were nonsyndromic and 11 of 19 (58%) were syndromic. Abnormal brain MRI findings were most common in syndromic children with combined OSA and CSA without adenotonsillar hypertrophy. Isolated OSA was also a common PSG finding associated with an abnormal brain MRI. Of the nonsyndromic children with an abnormal brain MRI, the most common abnormal brain MRI finding was Chiari malformation (CM), observed in 88% of the group. A brainstem tumor was identified in one nonsyndromic child. Interventions following brain MRI included neurosurgery, chemotherapy, and noninvasive positive pressure ventilation (NiPPV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A brain MRI is an important diagnostic tool in syndromic and nonsyndromic children, especially in children with either isolated OSA or combined OSA and CSA without a clear etiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 2016 127:513\u2013519, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26042","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T10:52:56Z","timestamp":1462272776000},"page":"513-519","source":"Crossref","is-referenced-by-count":13,"title":["Utility of brain MRI in children with sleep\u2010disordered breathing"],"prefix":"10.1002","volume":"127","author":[{"given":"Sarah","family":"Selvadurai","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine Hospital for Sick Children Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhail","family":"Al\u2010Saleh","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Hospital for Sick Children Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshma","family":"Amin","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Hospital for Sick Children Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Zweerink","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Drake","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Hospital for Sick Children Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan J.","family":"Propst","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Hospital for Sick Children Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indra","family":"Narang","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Hospital for Sick Children Toronto Ontario Canada"},{"name":"University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.1.2008171"},{"key":"e_1_2_6_3_1","first-page":"311","article-title":"Sleep disordered breathing in children","volume":"131","author":"Sinha D","year":"2010","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1930OC"},{"key":"e_1_2_6_5_1","first-page":"1147","article-title":"Obstructive sleep apnea in children","volume":"69","author":"Chan J","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21469"},{"key":"e_1_2_6_7_1","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.0.2","author":"Berry RB","year":"2013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06.2287"},{"key":"e_1_2_6_9_1","first-page":"350","article-title":"Nocturnal hypoventilation\u2014identifying and treating syndromes","volume":"131","author":"Piper AJ","year":"2010","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101012"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815583459"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811400683"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.1.1830175"},{"key":"e_1_2_6_14_1","unstructured":"PropstEJ AminR ZweerinkA et al.Midline posterior glossectomy and lingual tonsillectomy in obese and non\u2010obese children with down syndrome. 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