{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:43:19Z","timestamp":1789882999498,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The purpose of this study was to report the outcomes of a retrospective consecutive cohort study of patients with T1N0M0 glottic carcinoma treated with 4\u2010MV or 6\u2010MV radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of all patients with T1N0M0 glottic carcinoma treated with radiotherapy between January 2000 and December 2012 in the Department of Radiation Oncology at National Cancer Center Singapore. A total of 124 patients were included. Clinical endpoints of interest were: local control (LC), overall survival (OS), and disease\u2010specific survival (DSS). Other prognostic factors for LC were also analyzed: age, gender, smoking status, T substage, dose fraction, field size, anterior commissure involvement, total dose, and overall treatment time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six\u2010megavolt photon radiotherapy was used in 73 patients and 4\u2010MV photon radiotherapy in 51 patients. Median follow\u2010up was 4.9 years. The 5\u2010year LC and OS were as follows: 4 MV, 91.6% and 83.4%; 6 MV, 88.8% and 82.8%; and the 5\u2010year LC, OS, and DSS for all patients were 90.4%, 83.3%, and 98.3%. There was no significant difference in LR and OS between 4\u2010MV and 6\u2010MV radiotherapy (<jats:italic>P<\/jats:italic> = .92, <jats:italic>P<\/jats:italic> = .16, respectively). In the univariate analysis of LC, none of the prognostic factors was statistically significant. Twenty patients (23%) developed second primary cancers, the majority in the lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Six\u2010megavolt photon radiotherapy yields comparable results to 4\u2010MV photons. Bolus and computed tomographic simulation are useful to ensure adequate dose coverage of target volume. Follow\u2010up postradiotherapy should incorporate chest imaging, smoking cessation advice, and thyroid function test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 127:1061\u20131067, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26067","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T11:27:08Z","timestamp":1464607628000},"page":"1061-1067","source":"Crossref","is-referenced-by-count":4,"title":["Comparison between 4\u2010MV and 6\u2010MV radiotherapy in T1N0 glottic cancer"],"prefix":"10.1002","volume":"127","author":[{"given":"Kiattisa","family":"Sommat","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Ling Fung","family":"Yit","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Cancer Center Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Lian","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Clinical Trials and Epidemiology National Cancer Center Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-193"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00613-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu203"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90230-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00635-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(96)01738-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00431-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<381::AID-CNCR22>3.0.CO;2-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-53"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(03)00059-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11575"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)02205-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.20.4029"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(96)01796-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00578-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00284-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869009090067"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-004-1164-y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199612000-00020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.10.010"},{"key":"e_1_2_7_22_1","unstructured":"Royal College of Radiologists. 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