{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:06:48Z","timestamp":1778900808943,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The effect of smoking and human papillomavirus (HPV) on overall survival (OS) of oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing concurrent chemotherapy (CCRT) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical characteristics of OPSCC patients treated between 2008 and 2015 with CCRT were abstracted from medical records. OS curves and multivariate cox proportional hazard ratios (HRs) were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 120 evaluable patients, 71% had HPV<jats:sup>+<\/jats:sup> tumors. Median follow\u2010up duration for the entire cohort was 41.5 months (range = 6\u201388 months). HPV<jats:sup>+<\/jats:sup> current smokers experienced significantly worse 5\u2010year OS (73% alive vs. 36% alive, <jats:italic>P<\/jats:italic> = .01) and there was a similar trend in HPV<jats:sup>\u2212<\/jats:sup> current smokers (66% alive vs. 31% alive, <jats:italic>P<\/jats:italic> = .28) compared to former\/never smokers undergoing CCRT. In a multivariate cox proportional hazard model adjusted for age, gender, and overall tumor stage, HPV<jats:sup>+<\/jats:sup> current smokers experienced nearly a fourfold increase in overall mortality in comparison to HPV<jats:sup>+<\/jats:sup> never\/former smokers (HR = 3.68, 95% CI = 1.35\u201010.0). Similarly, current smokers with HPV<jats:sup>\u2212<\/jats:sup> tumors (HR = 6.80, 95% CI = 1.11\u201041.67) had increased mortality compared to never\/former smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Current smoking is associated with poor prognosis, independent of HPV status, in CCRT\u2010treated OPSCC patients. Current smoking produced an approximately four\u2010 to sevenfold increase in risk of mortality for HPV<jats:sup>+<\/jats:sup> and HPV<jats:sup>\u2212<\/jats:sup> patients, respectively. Regardless of pack years and HPV status, efforts should be made to achieve smoking cessation before CCRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 126:2733\u20132738, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26083","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T09:14:45Z","timestamp":1467018885000},"page":"2733-2738","source":"Crossref","is-referenced-by-count":42,"title":["Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation"],"prefix":"10.1002","volume":"126","author":[{"given":"Alexis J.","family":"Platek","sequence":"first","affiliation":[{"name":"Department of Radiation Medicine Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayvel","family":"Jayaprakash","sequence":"additional","affiliation":[{"name":"Head and Neck\/Plastic and 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