{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:20Z","timestamp":1786978160492,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>To assess safety and efficacy of a steroid\u2010releasing implant in improving surgical outcomes when placed in the frontal sinus opening (FSO) following endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective, multicenter, randomized, blinded trial using an intrapatient control design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty adult (\u2265 18 years) CRS patients who underwent successful bilateral frontal sinusotomy were randomized to receive a steroid\u2010releasing implant in one FSO, whereas the contralateral control side received no implant. All patients received standard postoperative care. Endoscopic evaluations recorded at 30\u2010days postendoscopic sinus surgery (ESS) were graded real time by clinical investigators and by an independent, blinded sinus surgeon to assess the need for postoperative interventions in the FSO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Implants were successfully placed in all 80 frontal sinuses, resulting in 100% implant delivery success. At 30\u2010days post\u2010ESS, steroid\u2010releasing implants provided a statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0070) reduction in the need for postoperative interventions compared to surgery alone by an independent reviewer, representing 38% relative reduction. Clinical investigators reported statistically significant reduction in this measure at 30 days (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) and 90 days (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0129). Clinical investigators also reported a 55.6% reduction in the need for oral steroid interventions (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0015), 75% reduction in the need for surgical interventions (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0225), 16.7% reduction in inflammation score, 54.3% reduction in restenosis rate (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0002), and 32.2% greater diameter of FSO (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001) on treated sides compared to control at 30 days. No implant\u2010related adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the efficacy of steroid\u2010releasing implants in improving outcomes of frontal sinus surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      1b.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 126:2659\u20132664, 2016\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.26140","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T06:38:20Z","timestamp":1467355100000},"page":"2659-2664","source":"Crossref","is-referenced-by-count":66,"title":["Randomized controlled trial of a bioabsorbable steroid\u2010releasing implant in the frontal sinus opening"],"prefix":"10.1002","volume":"126","author":[{"given":"Timothy L.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Oregon Health Sciences University Portland Oregon U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Surgery and Neurosurgery George Washington Medical Faculty Associates Washington DC U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology McGovern Medical School at the University of Texas Health Science Center of Houston Houston Texas U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall A.","family":"Ow","sequence":"additional","affiliation":[{"name":"Sacramento ENT Roseville California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Shotts","sequence":"additional","affiliation":[{"name":"Advanced ENT and Allergy Louisville Kentucky U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan B.","family":"Sautter","sequence":"additional","affiliation":[{"name":"Providence St. Vincent Medical Center Portland Oregon U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Han","sequence":"additional","affiliation":[{"name":"Divisions of Rhinology and Endoscopic Sinus\u2010Skull Base Surgery and Allergy Eastern Virginia Medical School Norfolk Virginia U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Stambaugh","sequence":"additional","affiliation":[{"name":"Intersect ENT Menlo Park California 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