{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:27Z","timestamp":1792020807984,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["U24 DC011968"],"award-info":[{"award-number":["U24 DC011968"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001873","name":"Starkey Hearing Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To measure the volume of the endolymph drainage system in temporal bone specimens with M\u00e9ni\u00e8re disease, as compared with specimens with endolymphatic hydrops without vestibular symptoms and with nondiseased specimens<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Comparative human temporal bone analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We generated three\u2010dimensional models of the vestibular aqueduct, endolymphatic sinus and duct, and intratemporal portion of the endolymphatic sac and calculated the volume of those structures. We also measured the internal and external aperture of the vestibular aqueduct, as well as the opening (if present) of the utriculoendolymphatic (Bast's) valve and compared the measurements in our three study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The volume of the vestibular aqueduct and of the endolymphatic sinus, duct, and intratemporal endolymphatic sac was significantly lower in the M\u00e9ni\u00e8re disease group than in the endolymphatic hydrops group (<jats:italic>P<\/jats:italic> &lt;.05). The external aperture of the vestibular aqueduct was also smaller in the M\u00e9ni\u00e8re disease group. Bast's valve was open only in some specimens in the M\u00e9ni\u00e8re disease group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In temporal bones with M\u00e9ni\u00e8re disease, the volume of the vestibular aqueduct, endolymphatic duct, and intratemporal endolymphatic sac was lower, and the external aperture of the vestibular aqueduct was smaller as compared with bones from donors who had endolymphatic hydrops without vestibular symptoms and with nondiseased bones. The open status of the Bast's valve in the M\u00e9ni\u00e8re disease group could be secondary to higher retrograde endolymph pressures caused by smaller drainage systems. These anatomic findings could correlate with the reason that some patients with hydrops develop clinical symptoms, whereas others do not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>N\/A <jats:italic>Laryngoscope<\/jats:italic>, 127:E170\u2013E175, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26155","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T06:47:14Z","timestamp":1469083634000},"source":"Crossref","is-referenced-by-count":32,"title":["A three\u2010dimensional analysis of the endolymph drainage system in M\u00e9ni\u00e8re disease"],"prefix":"10.1002","volume":"127","author":[{"given":"Rafael da Costa","family":"Monsanto","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota U.S.A."},{"name":"Department of Otolaryngology and Head and Neck Surgery Banco de Olhos de Sorocaba Hospital Sorocaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique F.","family":"Pauna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota U.S.A."},{"name":"Department of Otolaryngology and Head and Neck Surgery Campinas State University Campinas S\u00e3o Paulo Brazil ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeyoun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Schachern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Tsuprun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Paparella","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota U.S.A."},{"name":"Paparella Ear, Head, &amp; Neck Institute Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahattin","family":"Cureoglu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Minnesota Minneapolis Minnesota U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109128041"},{"key":"e_1_2_7_3_1","first-page":"2310","article-title":"Hearing organ of a patient who showed Meniere's symptoms","volume":"44","author":"Yamakawa K","year":"1938","journal-title":"J Otolaryngol Soc Jpn"},{"key":"e_1_2_7_4_1","first-page":"1317","article-title":"Observations on the pathology of Meniere's syndrome: (Section of Otology)","volume":"31","author":"Hallpike CS","year":"1938","journal-title":"Proc R Soc Med"},{"key":"e_1_2_7_5_1","first-page":"343","article-title":"Membranous hydrops in the inner ear of the guinea pig after the obliteration of the endolymphatic sac","volume":"27","author":"Kimura RS","year":"1965","journal-title":"Pract Otorhinolaryngol"},{"key":"e_1_2_7_6_1","first-page":"10","article-title":"Pathogenesis of Meniere's disease and Meniere's syndrome","volume":"406","author":"Paparella MM","year":"1984","journal-title":"Acta Otolaryngol Suppl"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894840930S406"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00019-1"},{"key":"e_1_2_7_9_1","first-page":"189","article-title":"Meniere's disease. 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