{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:03:22Z","timestamp":1760299402698},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)\/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following approval by the institutional review board at the Wexner Medical Center at the Ohio State University, Columbus, Ohio, a pilot study with retrospective review of patients with biopsy\u2010proven diagnosis of ONB s and SNUC s was conducted. Staging PET\/CT scans were reviewed to document the maximum standardized uptake value (SUVmax). A statistical comparison of SUVmax was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 13 patients (7 with ONBs and 6 with SNUCs) with mean age 60.2 years who had undergone staging F\u201018 fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) PET\/CT of the primary tumor at the time of their diagnosis. Mean SUVmax was found to be five\u2010fold higher in SNUC patients (35.63, range 10.8\u201377.9) than in ONB patients (7.24, range 4.6\u201310.7) (<jats:italic>P \u2264<\/jats:italic> 0.00169).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maximum standardized uptake value of <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT can be used to initially discriminate between ONB and SNUC. This finding may prove helpful to guide diagnostic and treatment planning when the histopathologic diagnosis is inconclusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 2016 127:321\u2013324, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26194","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T12:50:07Z","timestamp":1470228607000},"page":"321-324","source":"Crossref","is-referenced-by-count":27,"title":["Role of <sup>18<\/sup>F\u2010FDG PET\/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma"],"prefix":"10.1002","volume":"127","author":[{"given":"Ahmad H.","family":"Elkhatib","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University Wexner Medical Center Ohio U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuba","family":"Soldatova","sequence":"additional","affiliation":[{"name":"College of Medicine The Ohio State University Columbus Ohio U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo L.","family":"Carrau","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University Wexner Medical Center Ohio U.S.A"},{"name":"Department of Neurological Surgery The Ohio State University Wexner Medical Center Ohio U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph Abi","family":"Hachem","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University Wexner Medical Center Ohio U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Ditzel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hospital Santa Cruz Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raewyn","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Royal Prince Alfred Hospital Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Prevedello","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery The Ohio State University Wexner Medical Center Ohio U.S.A"},{"name":"Department of Neurological Surgery The Ohio State University Wexner Medical Center Ohio U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Prevedello","sequence":"additional","affiliation":[{"name":"Department of Radiology The Ohio State University Wexner Medical Center Ohio U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo F. 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