{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:25:46Z","timestamp":1773458746769,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T00:00:00Z","timestamp":1470441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To analyze clinical presentations, treatment modalities, and evolution of pediatric cases of salivary gland carcinomas to standardize care for these rare diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Multicentric, retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included in this retrospective study all children and adolescents (aged \u226418 years) treated from 1992 to 2012 in six pediatric centers in Paris, France. Pathological tumor specimens of these cases were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010three children were included (sex ratio male\/female = 19\/24, median age = 13 years). The parotid gland was the most common (37 cases) location for tumors. Histological subtypes were mucoepidermoid carcinomas (n = 20), acinic cell carcinomas (n = 14), and other (n = 9). Initial fine\u2010needle aspiration was performed in 15 cases (33%), and was concordant to final diagnosis in three cases (20%). Primary surgery was performed in 42 patients, leading to a complete microscopic resection in 80%. Associated lymph node dissection was performed in 28 patients (homolateral: 27, bilateral: 1) and showed lymph node metastases in only two patients. One patient had distant metastases. Adjuvant irradiation was delivered to 11 patients (median: 60 Gy; range: 50\u201365) and chemotherapy in five cases. After a median follow\u2010up of 5 years, six tumors relapsed, but no deaths occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Childhood salivary gland carcinomas have a good prognosis despite possible recurrences. Treatment is mainly based on surgery, with simultaneous node dissection in cases of clinical or radiologic node enlargement. Radiation therapy seems to be restricted to inoperable high\u2010grade tumors or after recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 127:140\u2013147, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26204","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T12:38:52Z","timestamp":1470487132000},"page":"140-147","source":"Crossref","is-referenced-by-count":39,"title":["Pediatric salivary gland carcinomas: Diagnostic and therapeutic management"],"prefix":"10.1002","volume":"127","author":[{"given":"C\u00e9leste","family":"Rebours","sequence":"first","affiliation":[{"name":"Pediatric Ear, Nose, and Throat Department Necker Hospital for Sick Children, Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Couloigner","sequence":"additional","affiliation":[{"name":"Pediatric Ear, Nose, and Throat Department Necker Hospital for Sick Children, Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Galmiche","sequence":"additional","affiliation":[{"name":"Department of Pathology, Necker Hospital for Sick Children Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile","family":"Casiraghi","sequence":"additional","affiliation":[{"name":"Department of Pathology Gustave Roussy Institute Grand Campus Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Badoual","sequence":"additional","affiliation":[{"name":"Department of Pathology Georges Pompidou European Hospital, Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabah","family":"Boudjemaa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Armand Trousseau Hospital Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Chauvin","sequence":"additional","affiliation":[{"name":"Paris Diderot University, Sorbonne Paris Cit\u00e9, Public Assistance\u2010Hospitals of Paris, Lariboisi\u00e8re Hospital, Emergency Services Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Elmaleh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Robert Debr\u00e9 Hospital Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brice","family":"Fresneau","sequence":"additional","affiliation":[{"name":"Pediatric Department Gustave Roussy Institute Grand Campus Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Fasola","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Department Armand Trousseau Hospital, Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erea\u2010No\u00ebl","family":"Garab\u00e9dian","sequence":"additional","affiliation":[{"name":"Pediatric Ear, Nose, and Throat Department Necker Hospital for Sick Children, Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Van Den Abeele","sequence":"additional","affiliation":[{"name":"Pediatric Ear, Nose, and Throat Department, Robert Debr\u00e9 Hospital Public Assistance\u2010Hospitals of Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[{"name":"Pediatric, Adolescent, and Young Adult Department Curie Institute Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Pediatric French Rare Tumor Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.11.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000026"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1165-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20637"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.11.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25139"},{"key":"e_1_2_7_8_1","unstructured":"French Network of Rare Head and Neck Tumors. 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