{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:05:22Z","timestamp":1788829522610,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T00:00:00Z","timestamp":1472601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>Evaluate the oncologic outcomes of patients with early and select advanced primary glottic squamous cell carcinoma (SCCa) managed by transoral laser microsurgery (TLM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety cases of TLM\u2010managed primary glottic SCCa were identified retrospectively using a prospectively collected database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Outcomes of patients with pTis\u2013pT2a disease (n = 65) and pT2b\u2013pT4a disease (n = 25) were, respectively: 5\u2010year local control, 86.2% and 67.5%; 5\u2010year disease\u2010free survival, 64.9% and 44.9%; 5\u2010year disease\u2010specific survival, 96.4% and 59.0%; laryngeal preservation, 96.9% and 80%. Five of nine patients (56%) with supraglottic\u2013glottic\u2013subglottic tumors were local recurrence\u2010free compared to the 70 of 81 (86%) patients with glottic, supraglottic\u2013glottic, and glottic\u2013subglottic tumors. Seven of 13 patients (54%) with positive or indeterminate margins were local recurrence\u2010free compared to 68 of 77 (88%) patients with negative margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given sample size considerations, this study highlights the satisfactory oncologic outcomes of TLM\u2010treated glottic cancer and the potential importance of margin management and disease extension within the larynx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      4\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 127:597\u2013604, 2017\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.26207","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T02:39:59Z","timestamp":1472611199000},"page":"597-604","source":"Crossref","is-referenced-by-count":39,"title":["Management of primary T1\u2013T4 glottic squamous cell carcinoma by transoral laser microsurgery"],"prefix":"10.1002","volume":"127","author":[{"given":"Andrew T.","family":"Day","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Johns Hopkins University School of Medicine Baltimore Maryland U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in Saint Louis School of Medicine Saint Louis Missouri U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Nussenbaum","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in Saint Louis School of Medicine Saint Louis Missouri U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in Saint Louis School of Medicine Saint Louis Missouri U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce H.","family":"Haughey","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Florida Hospital Celebration Health Celebration Florida U.S.A"},{"name":"Department of Surgery University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_6_3_1","first-page":"111","volume-title":"World Health Organization Classification of Tumours. 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