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The six patients also had <jats:italic>POU3F4<\/jats:italic> variants, and a genetic analysis revealed frameshift deletions in three patients, a missense variant in two patients of the same family, and a large deletion in one patient. Three of the six patients with <jats:italic>POU3F4<\/jats:italic> variants were sporadic cases, and in one patient the genetic mutation occurred de novo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was indicated that <jats:italic>POU3F4<\/jats:italic> mutations can be predicted by incomplete partition type III anomaly by radiological examination of the inner ear. All six of the patients showed mixed hearing loss, but none showed fluctuations in hearing, which may be related to the lack of vestibular aqueduct enlargement at the operculum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 127:1663\u20131669, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26245","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T06:33:28Z","timestamp":1472625208000},"page":"1663-1669","source":"Crossref","is-referenced-by-count":14,"title":["Frequency and specific characteristics of the incomplete partition type III anomaly in children"],"prefix":"10.1002","volume":"127","author":[{"given":"Ayako","family":"Kanno","sequence":"first","affiliation":[{"name":"Division of Hearing and Balance Research National Institute of Sensory Organs National Hospital Organization Tokyo Medical Center Tokyo Japan"},{"name":"Department of Otolaryngology Inagi Municipal Hospital Tokyo Japan"},{"name":"Department of Otolaryngology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Mutai","sequence":"additional","affiliation":[{"name":"Division of Hearing and Balance Research National Institute of Sensory Organs National Hospital Organization Tokyo Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Namba","sequence":"additional","affiliation":[{"name":"Division of Hearing and Balance Research National Institute of Sensory Organs National Hospital Organization Tokyo Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kobari General Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Chiba Children's Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Ogahara","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Kanagawa Children's Medical Center Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Sugiuchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kanto Rosai Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Division of Hearing and Balance Research National Institute of Sensory Organs National Hospital Organization Tokyo Medical Center Tokyo Japan"},{"name":"Medical Genetics Center National Hospital Organization Tokyo Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb19572.x"},{"key":"e_1_2_7_3_1","first-page":"758","article-title":"Nonsyndromic hearing impairment: unparalleled heterogeneity","volume":"60","author":"Camp G","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_4_1","unstructured":"VanCampG SmithRJH.Hereditary hearing loss homepage. 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