{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:13:12Z","timestamp":1768518792671,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T00:00:00Z","timestamp":1472601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The discovery of noninvasive biomarkers of chronic rhinosinusitis (CRS) is critical to enable our ability to provide prognostic information and targeted medical therapy. Epithelial P\u2010glycoprotein (P\u2010gp) is overexpressed in CRS and exists in an extracellular, secreted form. The objective of this study was to determine whether secreted P\u2010gp concentrations are elevated in CRS and can be used to predict disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Institutional review board\u2010approved study examining mucus concentrations of P\u2010gp in 36 patients (10 control, 16 CRS without nasal polyps [CRSsNP], and 10 CRS with nasal polyps [CRSwNP]). P\u2010gp concentrations were determined by enzyme\u2010linked immunosorbent assay and normalized to total protein (TP). Clinical indices of disease severity, including the Sino\u2010Nasal Outcomes Test (SNOT\u201022) and Lund\u2010Mackay score, were collected for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Secreted P\u2010gp concentration was significantly higher in CRS versus control patients (mean \u00b1 standard deviation; 247.8 \u00b1 224.8 vs. 102.4 \u00b1 81.7 pcg P\u2010gp\/\u03bcg TP, <jats:italic>P<\/jats:italic> = 0.022). A threshold value of 250 pcg\/\u03bcg TP was used to differentiate low versus high secretors. High P\u2010gp secretors with CRS (sNP and wNP, n = 9) demonstrated significantly higher SNOT\u201022 and Lund\u2010Mackay scores (57.1 \u00b1 7.9 and 13.9 \u00b1 7.3) versus low secretors (38.3 \u00b1 23.9 and 6.8 \u00b1 7.3; <jats:italic>P<\/jats:italic> = 0.030 and <jats:italic>P<\/jats:italic> = 0.013, respectively) and had a significantly higher proportion of CRSwNP (66.7%) versus the low secretors (23.5%, n = 17, <jats:italic>P<\/jats:italic> = 0.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>P\u2010gp secretion levels are significantly elevated in patients with CRS. High P\u2010gp secretion is associated with a higher incidence of CRSwNP and confers worse subjective and objective measures of disease severity. The presence of elevated P\u2010gp secretion may therefore represent a novel noninvasive biomarker of CRS and could be used to predict patients who may benefit from P\u2010gp inhibitory therapeutic strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 127:E1\u2013E4, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26249","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T06:33:13Z","timestamp":1472625193000},"source":"Crossref","is-referenced-by-count":22,"title":["Secreted P\u2010glycoprotein is a noninvasive biomarker of chronic rhinosinusitis"],"prefix":"10.1002","volume":"127","author":[{"given":"Angela L.","family":"Nocera","sequence":"first","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana T.","family":"Meurer","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel M.","family":"Miyake","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Sadow","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Harvard Medical School Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University Boston Massachusetts U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin S.","family":"Bleier","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary Harvard Medical School Boston Massachusetts 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