{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:12:53Z","timestamp":1772993573043,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yale University School of Medicine Lowe Endowment"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify and compare treatment and system factors associated with survival in early\u2010stage glottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective study of cases in the Commission on Cancer National Cancer Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients with early glottic cancer (stage I or II) diagnosed between January 1, 2004, and December 31, 2012, were included. Demographic, tumor, and survival variables were included in the analyses. Multivariate Cox regressions as well as univariate Kaplan\u2010Meier analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 5,627 patients were included in the study. Treatment factors associated with improved survival included larynx\u2010preserving surgery alone (hazard ratio [HR] 0.740; <jats:italic>P<\/jats:italic> = 0.001) and larynx\u2010preserving surgery with radiation (HR 0.837; <jats:italic>P<\/jats:italic> = 0.010) when compared to radiotherapy alone. System factors associated with worse survival included intermediate\u2010 (HR 1.123; <jats:italic>P<\/jats:italic> = 0.047) or low\u2010 (HR 1.458; <jats:italic>P<\/jats:italic> = 0.017) volume centers; Medicaid (HR 1.882; <jats:italic>P<\/jats:italic> &lt; 0.001), Medicare (HR 1.532; <jats:italic>P<\/jats:italic> &lt; 0.001), or other government insurance (HR 2.041; <jats:italic>P<\/jats:italic> &lt; 0.001); and delay between diagnosis and treatment greater than 100 days (HR 1.605; <jats:italic>P<\/jats:italic> = 0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A number of treatment and system factors were found to be significantly associated with survival when controlling for patient and tumor factors. These may present targets for the improvement of outcomes in early\u2010stage glottic cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 127:616\u2013622, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26259","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T11:06:52Z","timestamp":1474542412000},"page":"616-622","source":"Crossref","is-referenced-by-count":55,"title":["Treatment delay and facility case volume are associated with survival in early\u2010stage glottic cancer"],"prefix":"10.1002","volume":"127","author":[{"given":"Shayan","family":"Cheraghlou","sequence":"first","affiliation":[{"name":"Department of Surgery Yale School of Medicine New Haven Connecticut U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phoebe","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale School of Medicine New Haven Connecticut U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin L.","family":"Judson","sequence":"additional","affiliation":[{"name":"Department of Surgery Yale School of Medicine New Haven Connecticut U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Cancer Society.What are the key statistics about laryngeal and hypopharyngeal cancers?Available at:http:\/\/www.cancer.org\/cancer\/laryngealandhypopharyngealcancer\/detailedguide\/laryngeal\u2010and\u2010hypopharyngeal\u2010cancer\u2010key\u2010statistics. 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