{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:43:06Z","timestamp":1790023386561,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To prospectively assess symptoms before and after sialendoscopy\u2010assisted salivary duct surgery (SASDS) in patients with symptomatic sialadenitis without sialolithiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with chronic obstructive sialadenitis without sialolithiasis (COSWS) completed the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire prior to SASDS and 3 months postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 80 consecutive patients in a 20\u2010month period, 20 surveyed patients underwent SASDS for COSWS in 37 symptomatic glands. Major symptom improvement (&gt; 10 COSS score reduction) was reported in 24 of 37 (65%) of all glands, including 14 of 21 (67%) of radioactive iodine (RAI)\u2010induced cases and 10 of 13 (77%) of idiopathic sialadenitis cases. A significant reduction in postoperative mean COSS scores was seen overall (12.6 points, standard deviation [SD] 19.3, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 to a post\u2010SASDS mean score of 26.6). However, 19 of 37 (51%) glands demonstrated postoperative COSS scores above 25, denoting persistent disease. Mean COSS score reductions in RAI\u2010induced sialadenitis (12.4 points, SD 22.7, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and idiopathic sialadenitis (16.3 points, SD 13.7, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005) groups were significant, with post\u2010SASDS COSS mean scores of 30.6 (SD 19.8) and 20.8 (SD 13.8), respectively. Ducts with stenoses treated with dilation or sialodochoplasty showed significant COSS improvements of 21.1 (SD 17.9) and 12.4 points (SD 10.7), respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In a multivariate analysis, both the presence of stenosis and sialodochoplasty were independent predictors of complete or partial resolution (post\u2010COSS score\u2009&lt;\u200925) and major symptom improvement (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SASDS provides short\u2010term symptom reduction in patients with COSWS; particularly in RAI\u2010induced and idiopathic sialadenitis, and in duct stenosis amenable to dilation or sialodochoplasty. However, approximately half of the glands did not achieve meaningful symptom resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 127:1073\u20131079, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26308","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:08:37Z","timestamp":1476284917000},"page":"1073-1079","source":"Crossref","is-referenced-by-count":32,"title":["Sialadenitis without sialolithiasis: Prospective outcomes after sialendoscopy\u2010assisted salivary duct surgery"],"prefix":"10.1002","volume":"127","author":[{"given":"Elise A.","family":"Delagnes","sequence":"first","affiliation":[{"name":"School of Medicine University of California\u2013San Francisco San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Aubin\u2010Pouliot","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2013San Francisco San Francisco California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Medicine University of California\u2013San Francisco San Francisco California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolie L.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California\u2013San Francisco San Francisco California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Division of Head and Neck Oncologic and Endocrine Surgery University of California\u2013San Francisco San Francisco California 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