{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:03:04Z","timestamp":1779386584462,"version":"3.53.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the risk of tinnitus in patients with sleep disturbance or sleep apnea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 21,798 middle\u2010aged and elderly patients with otolaryngologist\u2010diagnosed tinnitus between January 1, 2000, and December 31, 2012, from the Longitudinal Health Insurance Database 2000 of the Taiwan National Health Insurance Research Database. A total of 108,990 controls were also identified from the same database based on frequency\u2010matching on 10\u2010year age interval, sex, and year of index date of the cases. Diagnoses of sleep disturbance (International Classification of Diseases, 9th Revision, Clinical Modification [ICD\u20109\u2010CM] codes 780.50, 780.52, 307.4) and sleep apnea (ICD\u20109\u2010CM codes 780.51, 780.53, 780.57) in the cases and controls prior to the index date were assessed. The risks of tinnitus in patients with sleep disturbance and sleep apnea were separately evaluated with multivariate logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the total 130,788 patients was 59.8 years, and 47% of them were males. The risk of tinnitus was higher in patients with sleep disturbance compared to those without the condition (adjusted odds ratio [OR] = 1.13, 95% confidence interval [CI] [95% CI] = 1.11\u20131.17), and the risk of tinnitus was higher in patients with sleep apnea compared to those without the condition (adjusted OR = 1.36, 95% CI = 1.16\u20131.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this population\u2010based, case\u2010control study, the risk of tinnitus was found to be significantly higher among middle\u2010aged and elderly Taiwanese patients with sleep disturbances, especially with sleep apnea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b. <jats:italic>Laryngoscope<\/jats:italic>, 127:2171\u20132175, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26323","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T06:48:54Z","timestamp":1474872534000},"page":"2171-2175","source":"Crossref","is-referenced-by-count":35,"title":["Risk of tinnitus in patients with sleep apnea: A nationwide, population\u2010based, case\u2010control study"],"prefix":"10.1002","volume":"127","author":[{"given":"Malcolm","family":"Koo","sequence":"first","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"},{"name":"Department of Medical Research Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Dalin Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juen\u2010Haur","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Dalin Chiayi Taiwan"},{"name":"Sleep Center Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Dalin Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi University Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"886","article-title":"Tinnitus: an epidemiologic study in Iranian population","volume":"51","author":"Jalessi M","year":"2013","journal-title":"Acta Med Iran"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.02.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127578"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000121"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150415002743"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/461090"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-861020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414532779"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941312201107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348941112000402"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)66021-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0973-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.9.1655"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.1998.tb01037.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2010.00860.x"},{"key":"e_1_2_7_17_1","unstructured":"National Health Insurance Administration Ministry of Health and Welfare Taiwan.National Health Insurance in Taiwan 2015\u20132016 Annual Report.2016. 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