{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:19:50Z","timestamp":1778775590746,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate subsite\u2010specific differences in survival between squamous cell carcinomas of the base of tongue and tonsillar fossa in a modern cohort likely to have been treated with intensity\u2010modulated radiation therapy, chemotherapy for stage III and IV, and have had a high incidence of human papillomavirus\u2013associated tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort analysis utilizing data from the Surveillance, Epidemiology, and End Results program of patients with base of tongue and tonsillar fossa squamous cell carcinoma from 2004 to 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort included 15,299 primary base of tongue and tonsillar fossa squamous cell carcinoma patients without distant metastases treated between 2004 and 2011. Subsite differences in overall survival and disease\u2010specific survival were examined with Kaplan\u2010Meier curves. Multivariate cox proportional hazard ratios were estimated for overall and disease\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 7,220 (47.2%) base of tongue and 8,079 (52.8%) tonsillar fossa squamous cell carcinoma patients. Overall survival with all stages combined favored tonsillar fossa (<jats:italic>P<\/jats:italic> &lt; .001) and remained superior when stratified by stage. In multivariate analyses adjusted for age, gender, race, and treatment, the hazard ratio for overall survival was superior for tonsillar fossa tumors compared to base of tongue tumors for all stages (stage 1, <jats:italic>P<\/jats:italic> = .041; stage 2, P = .006; stages 3 and 4, <jats:italic>P<\/jats:italic> &lt; .001). Disease\u2010specific survival also favored improved outcomes for tonsillar fossa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large modern cohort, overall and disease\u2010specific survival favored outcomes in tonsillar fossa compared with base of tongue. Further study is required to evaluate factors that influence survival differences between tonsillar fossa and base of tongue despite modern therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 127:1087\u20131092, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26369","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T11:36:25Z","timestamp":1478172985000},"page":"1087-1092","source":"Crossref","is-referenced-by-count":7,"title":["Subsite variation in survival of oropharyngeal squamous cell carcinomas 2004 to 2011"],"prefix":"10.1002","volume":"127","author":[{"given":"Mary E.","family":"Platek","sequence":"first","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayvel","family":"Jayaprakash","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Cohan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Wesley L.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy B.","family":"Winslow","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis J.","family":"Platek","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne","family":"Groman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Dibaj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moni A.","family":"Kuriakose","sequence":"additional","affiliation":[{"name":"Department of Head and Neck\/Plastic and Reconstructive Surgery Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham W.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Department of Cell and Molecular Pharmacology Medical University of South Carolina Charleston South Carolina U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anurag K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine Roswell Park Cancer Institute Buffalo New York U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32832984c0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104123441503"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200105000-00009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25625"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.09.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2007.08.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065497"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.04.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00560-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28372"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70346-1"},{"key":"e_1_2_6_16_1","unstructured":"Surveillance Epidemiology and End Results Program.Research data (1973\u20132008). National Cancer Institute website. Available at:http:\/\/seer.cancer.gov\/seerstat\/variables\/seer\/yr1973_2008\/lrd_stage."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20796"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860050215981"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0975-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.11.1196"},{"key":"e_1_2_6_22_1","unstructured":"The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General. U.S. Department of Health and Human Services website. Available at:http:\/\/www.surgeongeneral.gov\/library\/reports\/50\u2010years\u2010of\u2010progress\/full\u2010report.pdf. Accessed June 30 2016."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21549"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036515"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.2188"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27617"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010815)92:4<805::AID-CNCR1386>3.0.CO;2-9"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10960"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.07.006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2011.12.004"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26369","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lary.26369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:17:17Z","timestamp":1694117837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.26369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,3]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/lary.26369"],"URL":"https:\/\/doi.org\/10.1002\/lary.26369","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,3]]}}}