{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:38:13Z","timestamp":1782805093620,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T00:00:00Z","timestamp":1479254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#5T32 DC000022"],"award-info":[{"award-number":["#5T32 DC000022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Cranial nerve transection during head and neck surgery is conventionally repaired by microsuture reanastomosis. Laser nerve welding (LNW), using CO<jats:sub>2<\/jats:sub> laser to spot\u2010weld the epineurium of transected nerve endings, has been shown in animal models to be a novel alternative to microsuture repair. This method avoids needle\/suture material and minimizes instrumentation of the nerve. We hypothesized that potassium titanyl phosphate (KTP) laser would be superior to CO<jats:sub>2<\/jats:sub> laser in repairing transected nerves. Using a rat posterior tibial nerve injury model, we compared CO<jats:sub>2<\/jats:sub> laser, KTP laser, and microsuture reanastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Animals underwent unilateral posterior tibial nerve transection. The injury was repaired by microsuture repair (n = 15), CO<jats:sub>2<\/jats:sub> laser repair (n = 15), or KTP laser repair (n = 15). Weekly walking tracks were performed to measure functional recovery. Nerve segments were harvested for axon counting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6 weeks, the KTP LNW had the best functional recovery (92.4 \u00b1 8.6%) compared to microsuture repair (84.5 \u00b1 10.2%, difference 7.9%, 95% confidence interval [CI]: 0.84%\u201014.96%). CO<jats:sub>2<\/jats:sub> laser repair had a functional recovery of 86.8 \u00b1 11.2%. KTP LNW had better axon recovery compared to transection\/repair (difference 530.7 axons, 95% CI: 329.9\u2010731.5). Operative time for the microsuture repair was 18.2 \u00b1 6.8 minutes, compared to 5.8 \u00b1 3.7 minutes for the LNW groups (difference 12.4 minutes, 95% CI: 8.6\u201016.2 minutes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>KTP, CO<jats:sub>2<\/jats:sub>, and microsuture repair all showed good functional recovery following complete transection of the posterior tibial nerve. Following complete nerve transection during head and neck surgery, KTP LNW may be a novel alternative to microsuture repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 127:1525\u20131530, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26383","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T19:33:46Z","timestamp":1479324826000},"page":"1525-1530","source":"Crossref","is-referenced-by-count":8,"title":["Potassium titanyl phosphate laser welding following complete nerve transection"],"prefix":"10.1002","volume":"127","author":[{"given":"Neel K.","family":"Bhatt","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in Saint Louis St. Louis Missouri 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