{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:38:38Z","timestamp":1760985518201},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Determine disparities in survival outcome and clinical presentation between Hispanic and non\u2010Hispanic white patients with human papillomavirus\u2013positive oropharyngeal squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective clinical research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data on Hispanics and non\u2010Hispanic white patients with diagnosis of human papillomavirus\/p16\u2013positive oropharyngeal squamous cell carcinoma were drawn from a tumor registry from the University of Miami Hospitals and Clinics from 2008 to 2014.<\/jats:p><jats:p>Of 436 patients with oropharyngeal squamous cell carcinoma, 237 patents met inclusion criteria. Patient's age, gender, smoking history, alcohol history, race\/ethnicity, tumor T stage, nodal N stage, and composite TNM stage were included in the analysis. Associations between race and other categorical variables were explored with \u03c7<jats:sup>2<\/jats:sup> test or Fisher exact test where appropriate. Survival curves were generated using the Kaplan\u2010Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences in clinical presentation was detected between Hispanic (N = 70) and non\u2010Hispanic white (N = 167) patients. Hispanic human papillomavirus\u2013positive oropharyngeal squamous cell carcinoma patients showed a higher proportion of women with disease, a higher proportion of patients presenting with tonsil rather than tongue base primary subsite cancer, and a higher proportion of patients who do not consume alcohol compared to non\u2010Hispanic white human papillomavirus\u2013positive oropharyngeal squamous cell carcinoma patients. A statistically significant survival difference between these two ethnic groups was not detected in the current dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unique differences in clinical presentations between Hispanic patients and non\u2010Hispanic whites with human papillomavirus\u2013positive oropharyngeal squamous cell carcinoma were detected. This may be the first study to report novel clinical presentation in Hispanic human papillomavirus\u2013positive patients with oropharyngeal squamous cell carcinoma living in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 127:1097\u20131101, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26384","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T06:08:50Z","timestamp":1480313330000},"page":"1097-1101","source":"Crossref","is-referenced-by-count":4,"title":["Human papillomavirus\u2013induced oropharyngeal cancer in Hispanics in the United States"],"prefix":"10.1002","volume":"127","author":[{"given":"Giovana R.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Miami Miller School of Medicine Miami Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaming","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Biostatistics Collaboration and Consulting Core University of Miami Miller School of Medicine Miami Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Nwojo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Miami Miller School of Medicine Miami Florida U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.4596"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx500034c"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6995"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2015.03.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh074"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/649498"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0154"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.01.045"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9593-7"},{"key":"e_1_2_6_11_1","unstructured":"OrtmanJM GuarneriCE.United States population projections: 2000 to 2050. 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