{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:03:09Z","timestamp":1791946989384,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC005805"],"award-info":[{"award-number":["DC005805"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives\/Hypothesis<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disease process that is driven, in part, by intrinsic mucosal inflammation. Surgery plus continued medical therapy is commonly elected by medically recalcitrant, symptomatic patients. The objective was to evaluate the prevalence of nasal polyp recurrence up to 18 months after endoscopic sinus surgery (ESS) with congruent continuing medical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective, multicenter cohort of adult patients undergoing ESS for medically recalcitrant CRSwNP performed between August 2004 and February 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients received baseline nasal endoscopy quantified using Lund\u2010Kennedy grading. All patients included for final analysis provided at least 6 months of postoperative endoscopy examinations. Multivariate analysis was used to identify risk factors for polyp recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three hundred sixty\u2010three CRSwNP patients having undergone ESS involving polypectomy were enrolled. A total of 244 (67%) participants had graded postoperative endoscopies with average of follow\u2010up of 14.3 \u00b1 7.0 months. Surgery plus postoperative medical management significantly improved endoscopy total scores at 6 months (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). The recurrence of nasal polyposis 6 months after ESS was 35% (68\/197), compared to 38% (48\/125) after 12 months, and 40% (52\/129) after 18 months. Multivariate analysis identified both prior ESS (odds ratio [OR]: 2.6, 95% confidence interval [CI]: 1.5\u20104.6;\n                      <jats:italic>P<\/jats:italic>\n                      = .001) and worse preoperative polyposis severity (OR: 1.4, 95% CI: 1.1\u20101.8;\n                      <jats:italic>P<\/jats:italic>\n                      = .016) as risk factors for recurrent polyposis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Polyp recurrence is common after ESS with control of polyps up to 18 months found in approximately 60% to 70% of patients. Investigation into both surgical and medical management strategies is warranted to improve upon the observed prevalence of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      2c.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 127:550\u2013555, 2017\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.26391","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T10:59:23Z","timestamp":1479293963000},"page":"550-555","source":"Crossref","is-referenced-by-count":395,"title":["Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis"],"prefix":"10.1002","volume":"127","author":[{"given":"Adam S.","family":"DeConde","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Otolaryngology\u2013Head and Neck Surgery University of California\u2013San Diego San Diego California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess C.","family":"Mace","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus\/Skull Base Surgery Oregon Sinus Center, Department of Otolaryngology\u2013Head and Neck Surgery, Oregon Health and Science University Portland Oregon U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Division of Rhinology and Anterior Skull Base, Emory University Hospital Atlanta Georgia U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Rudmik","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah A.","family":"Alt","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Rhinology\u2013Sinus and Skull Base Surgery Program, Department of Surgery University of Utah Salt Lake City Utah U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus\/Skull Base Surgery Oregon Sinus Center, Department of Otolaryngology\u2013Head and Neck Surgery, Oregon Health and Science University Portland Oregon U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21065"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24213"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20653"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/000348941112000304","article-title":"Revision rates after endoscopic sinus surgery: a recurrence analysis","volume":"120","author":"Mendelsohn D","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21683"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23610"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21541"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25108"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21364"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770001-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.06.726"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"key":"e_1_2_7_17_1","first-page":"183","article-title":"Staging in rhinosinusitis","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00004"},{"key":"e_1_2_7_21_1","first-page":"131","article-title":"Comparison of radical (nasalisation) and functional ethmoidectomy in patients with severe sinonasal polyposis. 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