{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:50:31Z","timestamp":1770508231953,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Recurrent respiratory papillomatosis (RRP) is a disease with a high disease burden. Few studies have assessed quality of life (QoL) of RRP patients. This study compares QoL of these patients with controls. Associations between QoL and sociodemographic and illness\u2010related factors are examined, as is uptake of psychosocial care and speech therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective cross\u2010sectional questionnaire research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010one RRP patients (response = 67%) from two university hospitals in the Netherlands and Finland completed the following patient reported outcome measures: (HADS), 15\u2010dimensional health\u2010related quality\u2010of\u2010life scale (15D), Voice Handicap Index (VHI) and the RAND 36\u2010item health\u2010related quality\u2010of\u2010life survey instrument (RAND\u201036) assessing health\u2010related QoL and voice handicap, and they provided sociodemographic, illness\u2010related, and allied healthcare use. Descriptive analyses, \u03c7<jats:sup>2<\/jats:sup>tests,<jats:italic>t<\/jats:italic>tests, analysis of variance tests, and Pearson correlations were computed to describe the study population and to examine differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RRP patients had significantly higher mean scores on depression, health\u2010related QoL (15D) and on voice problems (VHI), and significantly lower mean scores on anxiety than controls. Dutch patients had more pain and a decreased general health perception (RAND\u201036) than controls. Dutch patients and older patients were more depressed, women were more anxious, older patients had lower health\u2010related QoL, and smoking was significantly associated with voice handicap. Patients who had received psychosocial care had significantly higher HADS\u2010depression mean scores than patients who did not receive psychosocial care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Having RRP has significant effect on voice\u2010related QoL and depression, but has no negative effect on anxiety and health\u2010related QoL. Risk factors for decreased functioning are different than previously hypothesized by many authors. Prevention should be aimed at these risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4.<jats:italic>Laryngoscope<\/jats:italic>, 127:1826\u20131831, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26413","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T17:37:35Z","timestamp":1479317855000},"page":"1826-1831","source":"Crossref","is-referenced-by-count":28,"title":["Quality of life of patients with recurrent respiratory papillomatosis"],"prefix":"10.1002","volume":"127","author":[{"given":"Michel R. M.","family":"San Giorgi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen the Netherlands"},{"name":"Cancer Research Center University of Groningen Groningen the Netherlands"},{"name":"Groningen Papilloma Studies University of Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena\u2010Maija","family":"Aaltonen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Helsinki, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Rihkanen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Helsinki, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin E. A.","family":"Tjon Pian Gi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen the Netherlands"},{"name":"Cancer Research Center University of Groningen Groningen the Netherlands"},{"name":"Groningen Papilloma Studies University of Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard F. A. M.","family":"van der Laan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery University Medical Center Groningen, University of Groningen Groningen the Netherlands"},{"name":"Cancer Research Center University of Groningen Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josette E. H. 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