{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:24:43Z","timestamp":1760909083426},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To evaluate the long\u2010term disease control, survival, and complications after definitive radiotherapy (RT) alone or combined with adjuvant chemotherapy with or without planned neck dissection for base of tongue squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>We retrospectively reviewed the medical records of 467 patients treated at the University of Florida with definitive RT alone or combined with adjuvant chemotherapy between 1964 and 2011 for base of tongue SCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Median follow\u2010up was 5.6 years. Median total dose to the primary site was 74.4 Gy. Eighty\u2010seven patients (19%) were treated with once\u2010daily fractionation, and 380 (81%) received altered fractionation schedules. Intensity\u2010modulated RT was used in 128 patients (27%). Chemotherapy was administered to 173 (37%) patients. Planned neck dissection after RT was performed in 226 patients (48%). Data regarding p16 pathway activation were available for 25 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 5 years, the local, local\u2013regional, and regional control rates were 85.5%, 80.0%, and 90.0%, respectively. The 5\u2010year overall, cause\u2010specific, and distant metastasis\u2010free survival rates were 59.1%, 71.5%, and 84.1%, respectively. Sixty\u2010four patients (14%) developed one or more severe late complications. Fifty patients (11%) required late gastrostomy tube placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports the continued use of RT alone or combined with adjuvant chemotherapy for patients with base of tongue SCC, as this treatment yields high rates of cause\u2010specific survival and disease control, with a relatively low rate of late complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 127:1589\u20131594, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26460","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T12:40:54Z","timestamp":1487940054000},"page":"1589-1594","source":"Crossref","is-referenced-by-count":5,"title":["Radiotherapy alone or combined with chemotherapy for base of tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"127","author":[{"given":"Kaitlin","family":"Christopherson","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Florida Gainesville Florida U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida Gainesville Florida U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Kirwan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida Gainesville Florida U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Amdur","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Florida Gainesville Florida U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Dziegielewski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Florida Gainesville Florida U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Boyce","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Florida Gainesville Florida U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Florida Gainesville Florida U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-015-0362-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23995"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1362-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10567"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.12.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)02028-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.10.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-133"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24059"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28372"},{"key":"e_1_2_6_12_1","volume-title":"American Joint Committee on Cancer (AJCC) Cancer Staging Manual","author":"Edge S","year":"2011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90975-N"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23739"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000141"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.1.36"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21021"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.04.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21669"},{"key":"e_1_2_6_20_1","first-page":"4411","article-title":"Detailed analysis of clinicopathologic factors demonstrate distinct difference in outcome and prognostic factors between surgically treated HPV\u2010positive and negative oropharyngeal cancer. 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