{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T02:29:23Z","timestamp":1775356163063,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102014R1A1A2058141"],"award-info":[{"award-number":["NRF\u20102014R1A1A2058141"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective, randomized, placebo\u2010controlled, double\u2010blinded, multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (<jats:italic>n<\/jats:italic> = 27) or an intratympanic normal saline injection (ITNI; <jats:italic>n<\/jats:italic> = 27) group through block randomization. Intratympanic injections were administered four times over 2 weeks. At 4 weeks after initial injection, we analyzed the improvement rates of tinnitus using the tinnitus handicap Inventory (THI) and visual analogue scale (VAS) for loudness, awareness, and annoyance. We defined improvement as the reduction of more than 7 points or of more than 20% in the final THI score compared to the initial THI score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial mean hearing thresholds and VAS and THI scores of the two groups did not differ significantly. At 4 weeks after initial injection, the mean VAS and THI scores of both groups had significantly reduced. However, the improvement rate did not differ significantly between the groups (ITDI, 51.9%; ITNI, 59.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicate that ITDI might not be more effective than ITNI for the treatment of acute unilateral tinnitus. Therefore, ITDI should not be considered as the main treatment for patients presenting with acute tinnitus as the primary symptom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b. <jats:italic>Laryngoscope<\/jats:italic>, 128:184\u2013188, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26541","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T06:09:01Z","timestamp":1487743741000},"page":"184-188","source":"Crossref","is-referenced-by-count":23,"title":["Clinical effect of intratympanic dexamethasone injection in acute unilateral tinnitus: A prospective, placebo\u2010controlled, multicenter study"],"prefix":"10.1002","volume":"128","author":[{"given":"Hyun\u2010Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Gyeongsang National University Changwon Hospital Changwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Beom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Young","family":"Yoo","sequence":"additional","affiliation":[{"name":"Ear and Hearing, Myung Dong Clinic Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi Nae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui\u2010Cheol","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kangwon National University, School of Medicine Chuncheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Seok","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"Soree Ear Clinic Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.102578"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22350"},{"key":"e_1_2_8_5_1","first-page":"129","article-title":"Treatment of cochlear\u2010tinnitus with dexamethasone infusion into the tympanic cavity","volume":"2","author":"Sakata E","year":"1996","journal-title":"Int Tinnitus J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24126"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890140029007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.127712"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21825"},{"key":"e_1_2_8_10_1","first-page":"Cd003852","article-title":"Ginkgo biloba for tinnitus","author":"Hilton MP","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00814.x"},{"key":"e_1_2_8_12_1","first-page":"501","article-title":"Trial of an extract of ginkgo biloba (EGB) for tinnitus and hearing loss","volume":"13","author":"Coles R","year":"1988","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1999.00243.x"},{"key":"e_1_2_8_14_1","first-page":"185","article-title":"A multicenter study of tinnitus. Epidemiology and therapy","volume":"103","author":"Meyer B","year":"1986","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S22793"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157574"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.11.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.4081\/audiores.2012.e2","article-title":"Intratympanic injection of dexamethasone for treatment of tinnitus in patients with sudden sensorineural hearing loss","volume":"2","author":"Yoshida T","year":"2012","journal-title":"Audiol Res"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.2.113"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109990685"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:03:21Z","timestamp":1696017801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.26541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/lary.26541"],"URL":"https:\/\/doi.org\/10.1002\/lary.26541","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]}}}