{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:38:10Z","timestamp":1788910690508,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF)"},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science, and Technology","doi-asserted-by":"crossref","award":["NRF-2015R1A2A15055956"],"award-info":[{"award-number":["NRF-2015R1A2A15055956"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science, ICT & Future Planning","award":["NRF-2015R1C1A1A02036457"],"award-info":[{"award-number":["NRF-2015R1C1A1A02036457"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Steroids have been widely used to treat inner\u2010ear diseases such as sudden sensorineural hearing loss, tinnitus, and Meniere's disease. They can be given via either systemic or intratympanic (IT) injection. The purpose of the present study was to explore differences in intracochlear steroid distribution by the administration method employed (systemic vs. IT injection).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three Sprague\u2010Dawley rats were given fluorescein isothiocyanate\u2010labeled dexamethasone (FITC\u2010DEX) three times (on successive days) via intraperitoneal (IP) or IT injection. Cochlear uptake of FITC\u2010DEX was evaluated via immunohistochemistry and flow cytometry at 6 hours, and 3 and 7 days after the final injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FITC\u2010DEX uptake was evident in spiral ganglion cells (SGs), the organ of Corti (OC), and the lateral walls (LWs), the basal turns of which were stained relatively prominently in both groups. Animals receiving IP injections exhibited higher FITC\u2010DEX uptakes by the SGs and OC, whereas IT injection triggered higher\u2010level FITC\u2010DEX accumulation by the OC and LWs. Flow cytometry revealed that intracochlear FITC\u2010DEX uptake by IT\u2010injected animals was higher and more prolonged than in animals subjected to IP injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We thus describe differences in cochlear steroid distributions after systemic and IT injections. This finding could help our understanding of the pharmacokinetics of steroids in the cochlea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA. <jats:italic>Laryngoscope<\/jats:italic>, 128:189\u2013194, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26562","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T09:50:47Z","timestamp":1489744247000},"page":"189-194","source":"Crossref","is-referenced-by-count":28,"title":["Steroid intracochlear distribution differs by administration method: Systemic versus intratympanic injection"],"prefix":"10.1002","volume":"128","author":[{"given":"Jong Joo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Ajou University School of Medicine Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hun","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Ajou 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