{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:06:30Z","timestamp":1792098390068,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Cranial nerve transection during head and neck surgery is conventionally repaired with microsuture. Previous studies have demonstrated recovery with laser nerve welding (LNW), a novel alternative to microsuture. LNW has been reported to have poorer tensile strength, however. Laser\u2010activated chitosan, an adhesive biopolymer, may promote nerve recovery while enhancing the tensile strength of the repair. Using a rat posterior tibial nerve injury model, we compared four different methods of nerve repair in this pilot study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Animals underwent unilateral posterior tibial nerve transection. The injury was repaired by potassium titanyl phosphate (KTP) laser alone (n = 20), KTP + chitosan (n = 12), microsuture + chitosan (n = 12), and chitosan alone (n = 14). Weekly walking tracks were conducted to measure functional recovery (FR). Tensile strength (TS) was measured at 6 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6 weeks, KTP laser alone had the best recovery (FR = 93.4% \u00b1 8.3%). Microsuture + chitosan, KTP + chitosan, and chitosan alone all showed good FR (87.4% \u00b1 13.5%, 84.6% \u00b1 13.0%, and 84.1% \u00b1 10.0%, respectively). One\u2010way analysis of variance was performed (<jats:italic>F<\/jats:italic>(3,56) = 2.6, <jats:italic>P<\/jats:italic> = .061). A TS threshold of 3.8 N was selected as a control mean recovery. Three groups\u2014KTP alone, KTP + chitosan, and microsuture + chitosan\u2014were found to meet threshold 60% (95% confidence interval [CI]: 23.1%\u201088.3%), 75% (95% CI: 46.8%\u201091.1%), and 100% (95% CI: 75.8%\u2010100.0%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the posterior tibial nerve model, all repair methods promoted nerve recovery. Laser\u2010activated chitosan as a biopolymer anchor provided good TS and appears to be a novel alternative to microsuture. This repair method may have surgical utility following cranial nerve injury during head and neck surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA <jats:italic>Laryngoscope<\/jats:italic>, 127:E253\u2013E257, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26583","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T02:37:35Z","timestamp":1490668655000},"source":"Crossref","is-referenced-by-count":10,"title":["Nerve transection repair using laser\u2010activated chitosan in a rat model"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-5477","authenticated-orcid":false,"given":"Neel K.","family":"Bhatt","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in St. Louis St. Louis Missouri U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taleef R.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in St. Louis St. Louis Missouri U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Mejias","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in St. Louis St. Louis Missouri U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal C.","family":"Paniello","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Washington University in St. Louis St. Louis Missouri 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