{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:17:25Z","timestamp":1789773445962,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Patients with empty nose syndrome (ENS) following turbinate surgery often complain about breathing difficulties. We set out to determine if dyspnea in patients with ENS was associated with hyperventilation syndrome (HVS). We hypothesized that lower airway symptoms in ENS could be explained by HVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Observational prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive patients referred to our center for ENS over 1 year were invited to participate. Patients completed the Nijmegen score and underwent a hyperventilation provocation test (HVPT) and arterial blood gas and cardiopulmonary tests. HVS was defined by a delayed return of the end\u2010tidal partial pressure of carbon dioxide in the expired gas to baseline during HVPT. Patients with HVS were asked to complete the Sinonasal Outcome Test (SNOT)\u201016 questionnaire before and after a specific eight\u2010session respiratory rehabilitation program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two of the 29 patients referred for ENS during the study period were eligible for inclusion and underwent a complete workup. HVS was diagnosed in 17 of these patients (77.3%). In the five patients who completed the SNOT\u201016, the score was significantly lower after rehabilitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that HVS is frequent in patients with ENS, and that symptoms can be improved by respiratory rehabilitation. Pathophysiological links between ENS and HVS deserve to be further explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b <jats:italic>Laryngoscope<\/jats:italic>, 127:1983\u20131988, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26599","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:02:42Z","timestamp":1492106562000},"page":"1983-1988","source":"Crossref","is-referenced-by-count":29,"title":["Investigating hyperventilation syndrome in patients suffering from empty nose syndrome"],"prefix":"10.1002","volume":"127","author":[{"given":"David","family":"Mangin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Facial Cervical Surgery Intercommunal Hospital Center of Cr\u00e9teil Cr\u00e9teil France"},{"name":"Department of Otorhinolaryngology and Facial Cervical Surgery Public Hospital Network of Paris, Henri Mondor Hospital Cr\u00e9teil 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and Medical Research INSERM, U955, Institut Mondor Recherche M\u00e9dical (IMRB) Cr\u00e9teil France"},{"name":"Faculty of Medicine Paris East University Cr\u00e9teil France"},{"name":"The national Center for Scientific Research CNRS, ERL 7240, Cr\u00e9teil, 94010, France"},{"name":"Department of Physiology and Functional Explorations Public Hospital Network of Paris, Henri Mondor Hospital Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Isabey","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research INSERM, U955, Institut Mondor Recherche M\u00e9dical (IMRB) Cr\u00e9teil France"},{"name":"Faculty of Medicine Paris East University Cr\u00e9teil France"},{"name":"The national Center for Scientific Research CNRS, ERL 7240, Cr\u00e9teil, 94010, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Louis","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research INSERM, U955, Institut Mondor Recherche M\u00e9dical (IMRB) Cr\u00e9teil France"},{"name":"Faculty of Medicine Paris East University Cr\u00e9teil France"},{"name":"The national Center for Scientific Research CNRS, ERL 7240, Cr\u00e9teil, 94010, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Adnot","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research INSERM, U955, Institut Mondor Recherche M\u00e9dical (IMRB) Cr\u00e9teil France"},{"name":"Faculty of Medicine Paris East University Cr\u00e9teil France"},{"name":"Department of Physiology and Functional Explorations Public Hospital Network of Paris, Henri Mondor Hospital Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Papon","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research INSERM, U955, Institut 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