{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:48:54Z","timestamp":1769737734924,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Evaluate morbidity and mortality rates for patients with different levels of hyperparathyroidism (HPT) undergoing parathyroidectomy (PTX), specifically comparing primary hyperparathyroidism to secondary and tertiary hyperparathyroidism. Assess predictive factors of increased morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective national database review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing PTX, defined by Current Procedural Terminology codes 60500, 60502, 60505, for the treatment of HPT, were identified in the American College of Surgeons National Surgical Quality Improvement Program database between 2006 and 2014. Incidence of morbidity and mortality was calculated for primary, secondary, and tertiary HPT. A <jats:italic>t<\/jats:italic> test, analysis of variance, and \u03c7<jats:sup>2<\/jats:sup> analyses were used to assess preoperative characteristics among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 21,267 patients were included in the analysis. There was an overall 7.2% morbidity and mortality rate, including 45 (0.21%) deaths, a 1.8% readmission rate, and a 1.9% reoperation rate, but morbidity and mortality rates were widely divergent when comparing primary to secondary and tertiary HPT. PTX resulted in a 4.9% morbidity and mortality rate for primary HPT (n = 14,500), 26.8% morbidity and mortality rate for secondary HPT (n = 1661), and 21.8% morbidity and mortality rate for tertiary HPT (n = 588). The primary reason for readmission was hypocalcemia (18.3%). Hematoma (7.2%) and postoperative hemorrhage (3.3%) were the two most common causes of reoperation. Elevated preoperative serum creatinine, alkaline phosphatase, and hypertension resulted in a higher rate of complications after PTX (<jats:italic>P<\/jats:italic> &lt; .0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although surgery for primary HPT is an extremely common and safe procedure with minimal morbidity and mortality rates, PTX for secondary and tertiary HPT has significantly higher rates of morbidity and mortality, requiring special attention in the postoperative period. Predictive factors of poor outcomes include hypertension, elevated creatinine, and elevated alkaline phosphatase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 128:528\u2013533, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26604","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T16:38:17Z","timestamp":1494520697000},"page":"528-533","source":"Crossref","is-referenced-by-count":38,"title":["Parathyroidectomy for the treatment of hyperparathyroidism: Thirty\u2010day morbidity and mortality"],"prefix":"10.1002","volume":"128","author":[{"given":"Jessica A.","family":"Tang","sequence":"first","affiliation":[{"name":"Chicago ENT: Advanced Center for Specialty Care Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Salapatas","sequence":"additional","affiliation":[{"name":"Chicago ENT: Advanced Center for Specialty Care Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren B.","family":"Bonzelaar","sequence":"additional","affiliation":[{"name":"Chicago ENT: Advanced Center for Specialty Care Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-1603","authenticated-orcid":false,"given":"Michael","family":"Friedman","sequence":"additional","affiliation":[{"name":"Chicago ENT: Advanced Center for Specialty Care Chicago Illinois U.S.A."},{"name":"Department of Otorhinolaryngology Rush University Medical Center Chicago Illinois U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816636842"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.013715"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01670531"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.2.142"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1177\/000313480607201218","article-title":"Hypocalcemia after neck exploration for untreated primary hyperparathyroidism","volume":"72","author":"Conn CA","year":"2006","journal-title":"Am Surg"},{"issue":"139","key":"e_1_2_6_7_1","first-page":"974","article-title":"Tertiary hyperparathyroidism: histologic patterns of disease and results of parathyroidectomy","volume":"004","author":"Kebebew E","journal-title":"Arch Surg"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.91483"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200205000-00009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1177\/000313480206801211","article-title":"Are preoperative serum calcium, parathyroid hormone, and adenoma weight predictive of postoperative hypocalcemia?","volume":"68","author":"Strickland PL","year":"2002","journal-title":"Am Surg"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/000313480407000204","article-title":"Post\u2010parathyroidectomy hypocalcemia: incidence, risk factors, and management","volume":"70","author":"Mittendorf EA","year":"2004","journal-title":"Am Surg"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.06.207"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1016-y"},{"key":"e_1_2_6_15_1","first-page":"827","article-title":"Relation of postoperative hypocalcemia to operative techniques: deleterious effect of excessive use of parathyroid biopsy","volume":"92","author":"Kaplan EL","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_6_16_1","first-page":"511","article-title":"Primary hyperparathyroidism due to solitary adenoma. 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