{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:27:21Z","timestamp":1791836841248,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"British Society of Audiology Applied Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Tinnitus is a prevalent condition, but little has been published regarding the natural history of the condition. One technique for evaluating the long\u2010term progression of the disease is to examine what happens to participants in the no\u2010intervention control arm of a clinical trial. The aim of this study was to examine no\u2010intervention or waiting\u2010list data reported in trials, in which participants on the active arm received any form of tinnitus intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>CINAHL, PsychINFO, EMBASE, ASSIA, PubMed, Web of Science, Science Direct, EBSCO Host, and Cochrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inclusion criteria followed the PICOS principles: Participants, adults with tinnitus; Intervention, none; Control, any intervention for alleviating tinnitus; Outcomes, a measure assessing tinnitus symptoms using a multi\u2010item patient\u2010reported tinnitus questionnaire. Secondary outcome measures included multi\u2010item patient\u2010reported questionnaires of mood and health\u2010related quality of life and measures that quantified change in tinnitus loudness; Study design, randomized controlled trials or observational studies utilizing a no\u2010intervention or waiting\u2010list control group. Data were extracted and standardized mean difference was calculated for each study to enable meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The evidence strongly favored a statistically significant decrease in the impact of tinnitus over time, though there was significant heterogeneity and clinical significance cannot be interpreted. Outcome data regarding secondary measures did not demonstrate any clinically significant change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Participants allocated to the no\u2010intervention or waiting\u2010list control arm of clinical trials for a tinnitus intervention show a small but significant improvement in self\u2010reported measures of tinnitus with time; the clinical significance of this finding is unknown. There is, however, considerable variation across individuals. These findings support previous work and can cautiously be used when counseling patients. <jats:italic>Laryngoscope<\/jats:italic>, 128:217\u2013227, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26607","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T09:12:18Z","timestamp":1492679538000},"page":"217-227","source":"Crossref","is-referenced-by-count":31,"title":["The natural history of subjective tinnitus in adults: A systematic review and meta\u2010analysis of no\u2010intervention periods in controlled trials"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-6283","authenticated-orcid":false,"given":"John S.","family":"Phillips","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Norfolk and Norwich University Hospital NHS Foundation Trust Norwich United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don J.","family":"McFerran","sequence":"additional","affiliation":[{"name":"Colchester Hospital University National Health Service Foundation Trust Colchester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Nottingham Hearing Biomedical Research Unit National Institute for Health Research Nottingham United Kingdom"},{"name":"Otology and Hearing Group Division of Clinical Neuroscience, School of Medicine, University of Nottingham  Nottingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Hoare","sequence":"additional","affiliation":[{"name":"Nottingham Hearing Biomedical Research Unit National Institute for Health Research Nottingham United Kingdom"},{"name":"Otology and Hearing Group Division of Clinical Neuroscience, School of Medicine, University of Nottingham  Nottingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.2.175"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1715975"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992021003753508"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00304-9"},{"key":"e_1_2_6_6_1","first-page":"113","article-title":"What happens when people wait for therapy? 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