{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:51:09Z","timestamp":1785775869380,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Acute supraglottitis is a potentially life\u2010threatening condition due to rapid onset upper airway obstruction. The study aimed to characterize adult acute supraglottitis patients and to recognize factors associated with an aggressive disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All adult acute supraglottitis patients admitted to a single academic medical center between 2000 and 2014 were included and their medical charts reviewed. The main outcome measures were airway intervention and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred fifty\u2010eight patients were enrolled. Mean age was 53 years (range, 16\u201392 years), with 62.8% males. Sore throat (79%) and dysphagia (70.9%) were the most common symptoms. Stridor (3.6%), tachypnea (5.7%), and dyspnea (6.4%) were uncommon but significantly associated with airway intervention. The epiglottis was most commonly involved (67%). Involvement of the epiglottis and aryepiglottic folds showed a trend of correlation to airway intervention. Blood glucose levels, C\u2010reactive protein (CRP) levels, and relative neutrophilia were significantly higher in patients admitted to the intensive care unit or requiring airway intervention. Thirty\u2010four patients (9.5%) required intensive care unit admission. Sixteen patients (4.4%) required airway intervention. Recurrent episodes of supraglottitis, seen in 19 patients, were more common in males (<jats:italic>P<\/jats:italic> = .048), and tended to have a more severe clinical course, requiring more airway interventions (<jats:italic>P<\/jats:italic> = .005) and intensive care unit admissions (<jats:italic>P<\/jats:italic> = .016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The typical high risk patient\u2014a male, with dyspnea and stridor, presenting with edema of the epiglottis and aryepiglottic folds, elevated CRP, hyperglycemia, and a history of recurrent episodes\u2014should warrant more aggressive treatment and closer observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4 <jats:italic>Laryngoscope<\/jats:italic>, 127:2106\u20132112, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26609","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T13:45:55Z","timestamp":1494510355000},"page":"2106-2112","source":"Crossref","is-referenced-by-count":29,"title":["Adult acute supraglottitis: Analysis of 358 patients for predictors of airway intervention"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-8534","authenticated-orcid":false,"given":"Yael","family":"Shapira Galitz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaplan Medical Center, Rehovot, Israel, affiliated with the Hebrew University of Jerusalem  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Shoffel\u2010Havakuk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaplan Medical Center, Rehovot, Israel, affiliated with the Hebrew University of Jerusalem  Israel"},{"name":"USC Voice Center, Department of Otolaryngology\u2013Head and Neck Surgery University of Southern California Los Angeles California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-3571","authenticated-orcid":false,"given":"Oded","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaplan Medical Center, Rehovot, Israel, affiliated with the Hebrew University of Jerusalem  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Halperin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaplan Medical Center, Rehovot, Israel, affiliated with the Hebrew University of Jerusalem  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-9235","authenticated-orcid":false,"given":"Yonatan","family":"Lahav","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Kaplan Medical Center, Rehovot, Israel, affiliated with the Hebrew University of Jerusalem  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"3051","volume-title":"Cummings Otolaryngology Head and Neck Surgery","author":"Meyer 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