{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:56:51Z","timestamp":1789772211572,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To establish a time frame for postoperative improvements in neurocognitive function in patients who undergo parathyroidectomy for primary hyperparathyroidism by utilizing repeat neuropsychological assessment at multiple time points before and after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective study was conducted at a tertiary academic medical center between August 2014 and December 2015, including 50 patients with primary hyperparathyroidism who underwent parathyroidectomy. A panel of neurocognitive tests was administered at two separate time points: preoperative and 1\u2010week postoperative. Validated neuropsychological assessment tools were utilized, including Rey Auditory\u2010Verbal Learning Test, Trail Making Test A and B, Benton Controlled Oral Word Association, WAIS\u2010IV Digit Span, Hospital Anxiety and Depression Scale, Positive and Negative Affect Schedule, and Insomnia Severity Index. Barona Information Sheet was used to collect demographic data. Paired\n                      <jats:italic>t<\/jats:italic>\n                      tests were to compare pre\u2010 and postoperative scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five patients completed the preoperative and 1\u2010week postoperative testing. In cognitive testing, significant improvement was noted in immediate recall (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), working memory (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.011), and attention (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.008) at 1\u2010week postoperative. In mood testing, depression (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), anxiety (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), and negative affect (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) scores were significantly improved at 1\u2010week postoperative. Insomnia scores also were significantly improved at 1 week (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Objective improvements in neurocognitive function following parathyroidectomy for primary hyperparathyroidism were noted as early as 1 week after surgery, which is earlier than previously reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>\n                      2b.\n                      <jats:italic>Laryngoscope<\/jats:italic>\n                      , 128:775\u2013780, 2018\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lary.26617","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T21:48:50Z","timestamp":1494971330000},"page":"775-780","source":"Crossref","is-referenced-by-count":29,"title":["Early neurocognitive improvements following parathyroidectomy for primary hyperparathyroidism"],"prefix":"10.1002","volume":"128","author":[{"given":"Shivani","family":"Shah\u2010Becker","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Derr","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin S.","family":"Oberman","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Baker","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Saunders","sequence":"additional","affiliation":[{"name":"Division of General Surgery Specialties and Surgical Oncology, Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Carr","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-4116","authenticated-orcid":false,"given":"David","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery, Department of Surgery The Pennsylvania State University, College of Medicine Hershey Pennsylvania U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0277"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2015.08.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199509000-00017"},{"key":"e_1_2_6_5_1","first-page":"72","article-title":"Self\u2010rated psychiatric symptoms in patients operated on because of primary hyperparathyroidism and in patients with long\u2010standing mild hypercalcemia","volume":"105","author":"Joborn C","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90128-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0444-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.08.033"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9006-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128606"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamasurg.316"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.52.5.885"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199311)49:6<883::AID-JCLP2270490616>3.0.CO;2-6"},{"key":"e_1_2_6_14_1","volume-title":"A Compendium of Neuropsychological Tests","author":"Strauss E","year":"2006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intell.2011.03.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6177(03)00039-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.11.1.138"},{"key":"e_1_2_6_18_1","volume-title":"Wechsler Adult Intelligence Scale","author":"Wechsler D","year":"2008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.54.6.1063"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00065-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.06.401"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688639508405143"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.4.338"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709990695"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:37:27Z","timestamp":1695699447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.26617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/lary.26617"],"URL":"https:\/\/doi.org\/10.1002\/lary.26617","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]}}}