{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:25:46Z","timestamp":1790267146169,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T00:00:00Z","timestamp":1494547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To determine the effect of radioactive iodine (RAI) treatment on the nasal mucosa and nasal functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 41 patients (31 female and 10 male) who were treated with RAI for papillary thyroid carcinoma. A visual analogue scale (VAS) was used for subjective evaluation of nasal symptoms. The saccharine test, nasal Schirmer test, and acoustic rhinometry were used for objective evaluation of nasal functions. All tests were administered at baseline (before RAI treatment), and then 1 month and 1 year post\u2010RAI treatment. Only 21 of the patients could be evaluated after 1 year of treatment and were included in the study's analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VAS obstruction and dryness scores 1 month and 1 year post\u2010RAI were significantly higher than the baseline scores (<jats:italic>P<\/jats:italic> &lt; .05 and <jats:italic>P<\/jats:italic> &lt; .05, respectively). Mean cross\u2010sectional area values 1 month and 1 year post\u2010RAI did not differ significantly from baseline values (<jats:italic>P<\/jats:italic> &gt; .05 and <jats:italic>P<\/jats:italic> &gt; .05, respectively). Schirmer test results 1 month and 1 year post\u2010RAI treatment were significantly lower than at baseline (<jats:italic>P<\/jats:italic> &lt; .05 and <jats:italic>P<\/jats:italic> &lt; .05, respectively). Saccharine test results 1 month and 1 year post\u2010RAI were significantly higher than at baseline (<jats:italic>P<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RAI treatment can adversely affect the nasal mucosa. Nasal dryness and obstruction can occur immediately after RAI treatment. Additional research is warranted to further elucidate the effects of RAI treatment on nasal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 127:2698\u20132702, 2017<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26652","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T14:26:44Z","timestamp":1494599204000},"page":"2698-2702","source":"Crossref","is-referenced-by-count":2,"title":["How does radioactive iodine affect the nose?"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-3605","authenticated-orcid":false,"given":"Ela Araz","family":"Server","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Kirgezen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem Onerci","family":"Celebi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-7345","authenticated-orcid":false,"given":"Muhammet","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery Gumu\u015fhane State Hospital Gumu\u015fhane Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of 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