{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:25:18Z","timestamp":1779269118108,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Intranasal bevacizumab injections have been used in treating hereditary hemorrhagic telangiectasia (HHT)\u2010related epistaxis since 2009. It is believed to be a safe and effective treatment for a selected group of HHT patients in reducing frequency and intensity of epistaxis, with few or none adverse effects. In this case report, however, we will describe a patient who developed bilateral osteonecrosis in the knees while undergoing regular intranasal submucosal bevacizumab injections. Although osteonecrosis previously has been documented in patients receiving bevacizumab intravenously in oncologic doses, thus far it has not been reported in patients treated with intranasal submucosal injections. <jats:italic>Laryngoscope<\/jats:italic>, 128:593\u2013596, 2018<\/jats:p>","DOI":"10.1002\/lary.26722","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T10:18:50Z","timestamp":1499077130000},"page":"593-596","source":"Crossref","is-referenced-by-count":9,"title":["Osteonecrosis after intranasal injection with bevacizumab in treating hereditary hemorrhagic telangiectasia: A case report"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-6043","authenticated-orcid":false,"given":"Johan","family":"Steineger","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Oslo University Hospital\u2013Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else","family":"Merckoll","sequence":"additional","affiliation":[{"name":"Department of Radiology Oslo University Hospital\u2013Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Magnar","family":"Sl\u00e5stad","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Oslo University Hospital\u2013Ullev\u00e5l Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik Fink","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oslo University Hospital\u2013Aker Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketil","family":"Heimdal","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Oslo University Hospital\u2013Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Dheyauldeen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Oslo University Hospital\u2013Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23303"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0155"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.02.001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6733"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.joms.2011.02.104","article-title":"Osteonecrosis after administration of intravitreous bevacizumab","volume":"70","author":"Hopp RN","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305252"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21345"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2141-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.05.009"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201108000-00004"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:39:32Z","timestamp":1695713972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.26722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/lary.26722"],"URL":"https:\/\/doi.org\/10.1002\/lary.26722","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,3]]}}}