{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T12:49:26Z","timestamp":1781354966284,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To compare outcomes of continuous positive airway pressure (CPAP) and the adjustable thermoplastic mandibular advancement splint (AT\u2010MAS) for obstructive sleep apnea treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Randomized crossover, noninferiority, tertiary center setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients with a mean age of 49.5 \u00b1 10.6 years were enrolled. Inclusion criteria were age \u226518 years, apnea\u2010hypopnea index (AHI) \u22655 events\/hour, and oxygen saturation \u226570%. Exclusion criteria were temporomandibular joint disorders, severe periodontitis, inadequate teeth, and unstable medical diseases. Treatment intolerance was considered a failure. Two\u2010week periods without treatment were followed by questionnaires and randomization into two groups: CPAP\/AT\u2010MAS (25) and AT\u2010MAS\/CPAP (25). After 6 weeks of intervention, questionnaires and home WatchPAT monitoring were performed. Following each 2\u2010week washout period, patients crossed over to the other treatment followed by similar procedures. Primary outcomes involved the scores from the Functional Outcomes of Sleep Questionnaire (FOSQ). Secondary outcomes were AHI, side effects, and treatment adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients withdrew from this study: five (AT\u2010MAS intolerance) and two (lost follow\u2010up). There was no significant difference among FOSQ scores, particularly on global scores, between both treatments (0.57, 95% confidential interval of difference: \u22120.15 to 1.29). Mean AHI decreased from pretreatment 39.2 \u00b1 2.53 to 2.56 \u00b1 0.49 and 12.92 \u00b1 2.05 events\/hour while using CPAP and the AT\u2010MAS, respectively (<jats:italic>P<\/jats:italic> &lt; .05). Most common side effects of CPAP were dry throat and inconvenience to carry, whereas those of the AT\u2010MAS were jaw pain and excessive salivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both devices improved short\u2010term quality of life similarly; however, the AT\u2010MAS was not as efficacious as CPAP on resolving sleep\u2010test parameters. The AT\u2010MAS might be considered only a temporary treatment alternative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b. <jats:italic>Laryngoscope<\/jats:italic>, 128:516\u2013522, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26753","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T09:08:50Z","timestamp":1500282530000},"page":"516-522","source":"Crossref","is-referenced-by-count":12,"title":["Adjustable thermoplastic oral appliance versus positive airway pressure for obstructive sleep apnea"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-6657","authenticated-orcid":false,"given":"Wish","family":"Banhiran","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok Thailand"},{"name":"Siriraj Sleep Center Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok 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