{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:55:53Z","timestamp":1792295753709,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to establish the significance of querying chronic rhinosinusitis (CRS) patients about their past CRS\u2010related oral antibiotic and corticosteroid usage by determining the association between these metrics and patients\u2019 quality of life (QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 157 patients with CRS were prospectively recruited. CRS\u2010specific QoL was measured using the 22\u2010item Sinonasal Outcome Test (SNOT\u201022). General health\u2010related QoL was measured using the EuroQoL five\u2010dimensional questionnaire visual analog scale. Associations were sought between these measures of QoL and frequency of CRS\u2010related oral antibiotic and corticosteroid usage reported by the participants in the prior 3 and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More frequent antibiotic and corticosteroid use was significantly associated with worse CRS\u2010specific and general health\u2010related QoL, whether querying medication use over the prior 3 months or over the prior 12 months (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 in all cases). The effect size of CRS\u2010related antibiotic use during the prior 3 months on CRS\u2010specific QoL (SNOT\u201022 score) was significantly greater than for use during the prior 12 months. However, there was no other statistically significant difference in effect size for association between QoL and CRS\u2010related antibiotic or corticosteroid use in the prior 3 months versus prior 12 months. These results were independent of the presence or absence of polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More frequent past CRS\u2010related oral antibiotic and corticosteroid use, regardless of time period queried (3 months or 12 months) is associated with significant decrease in CRS\u2010specific and general health\u2010related QoL. CRS\u2010related systemic medication use is an important indicator of CRS patients\u2019 QOL that easily can be queried and utilized in both clinical and research settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2c. <jats:italic>Laryngoscope<\/jats:italic>, 128:37\u201342, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26778","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T14:03:13Z","timestamp":1500645793000},"page":"37-42","source":"Crossref","is-referenced-by-count":31,"title":["Association between systemic antibiotic and corticosteroid use for chronic rhinosinusitis and quality of life"],"prefix":"10.1002","volume":"128","author":[{"given":"Alisa","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd P.","family":"Hoehle","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen L.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Caradonna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Division of Otolaryngology Beth Israel Deaconess Medical Center Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey T.","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Harvard Medical School Boston Massachusetts U.S.A"},{"name":"Department of Otolaryngology Massachusetts Eye and Ear Infirmary Boston Massachusetts 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