{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:16:23Z","timestamp":1788347783267,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:00:00Z","timestamp":1505520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Since first described in the 1990s, the endoscopic modified Lothrop procedure (EMLP) has been the subject of a growing body of literature. We performed a review to compare indications and outcomes of EMLP in an early cohort of publications (1990\u20132008) versus a contemporary cohort (2009\u20132016) and compare outcomes associated with follow\u2010up \u22652 years versus &lt;2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>PubMed, SCOPUS and Cochrane databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Review Methods<\/jats:title><jats:p>An English\u2010language search of the PubMed and Ovid databases was conducted to identify publications from 1990 to 2016 reporting clinical outcomes of EMLP. Meta\u2010analysis was performed using Statistical Analysis System 9.4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,205 patients were abstracted from 29 articles with a mean follow\u2010up of 29.1 \u00b1 10.3 months. The overall rate of significant or complete symptom improvement was 86.5% (95% confidence interval [CI]: 84.2%\u201088.7%). The overall patency rate was 90.7% (95% CI: 89.1%\u201092.3%), with a revision rate of 12.6% (95% CI: 10.6%\u201014.3%). Compared to the early cohort, patients in the contemporary cohort underwent EMLP more often for tumors (<jats:italic>P<\/jats:italic> &lt; .001), had higher rates of complete or significant symptom improvement (90.0% vs. 82.6 %, <jats:italic>P<\/jats:italic> &lt; .001); and trended toward greater patency rates (92.1% vs. 88.6%, <jats:italic>P<\/jats:italic> = .052). Compared to the short\u2010term follow\u2010up cohort, the long\u2010term cohort showed no differences in symptom improvement or patency, but the revision rate was higher (14.5% vs. 9.2%, <jats:italic>P<\/jats:italic> = .016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the last decade, EMLP has been performed more frequently for tumors. Recent studies have demonstrated improved symptom outcomes and a trend toward improved patency rates. The revision rate increased significantly when follow\u2010up exceeded 2 years. <jats:italic>Laryngoscope<\/jats:italic>, 128:317\u2013326, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26794","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:04:49Z","timestamp":1505743489000},"page":"317-326","source":"Crossref","is-referenced-by-count":34,"title":["Evolution of the endoscopic modified Lothrop procedure: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-6156","authenticated-orcid":false,"given":"Liang\u2010Chun","family":"Shih","sequence":"first","affiliation":[{"name":"Division of Rhinology and Endoscopic Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine Palo Alto California U.S.A."},{"name":"Division of Rhinology Department of Otolaryngology\u2013Head and Neck Surgery, China Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-5796","authenticated-orcid":false,"given":"Vishal S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Endoscopic Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine Palo Alto California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garret W.","family":"Choby","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Endoscopic Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine Palo Alto California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuguhisa","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Endoscopic Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine Palo Alto California U.S.A."},{"name":"Department of Otorhinolaryngology Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Endoscopic Skull Base Surgery Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine Palo Alto California U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-191406000-00014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1001\/archotol.1958.00730020281001","article-title":"Experiences with the osteoplastic anterior wall approach to the frontal sinus; case histories and recommendations","volume":"68","author":"Goodale RL","year":"1958","journal-title":"AMA Arch Otolaryngol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-1810(10)80087-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20565"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25648"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21695_c"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_7_9_1","unstructured":"PhillipsB BallC SackettD et al.Levels of evidence and grades of recommendation. 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