{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T12:41:04Z","timestamp":1782650464487,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T00:00:00Z","timestamp":1504310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007184","name":"Yale School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007184","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral cavity cancer is the most common malignant disease of the head and neck. The natural course of the disease is poorly characterized and unavailable for patient consideration during initial treatment planning. Our primary objective was to outline this natural history, with a secondary aim of identifying predictors of treatment refusal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective review of adult patients with oral cavity cancer who refused surgery that was recommended by their physician in the National Cancer Database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic, tumor, and survival variables were included in the analyses. Multivariate Cox regressions as well as univariate Kaplan\u2010Meier analyses were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who were older, uninsured, had government insurance, or had more advanced disease were more likely to go untreated. Survival among untreated patients was poor, but there was a small proportion of patients surviving long term. Five\u2010year survival rates ranged from 31.1% among early\u2010stage patients to 12.6% among stage 4 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the natural course of oral cavity cancer carries a poor prognosis, there are a number of patients with longer\u2010than\u2010expected survival. The survival estimates may provide supplemental information for patients deciding whether to pursue treatment. In addition to age and extent of disease, system factors such as insurance status and facility case volume are associated with a patient's likelihood of refusing treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 128:664\u2013669, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26809","type":"journal-article","created":{"date-parts":[[2017,9,2]],"date-time":"2017-09-02T08:53:08Z","timestamp":1504342388000},"page":"664-669","source":"Crossref","is-referenced-by-count":35,"title":["Untreated oral cavity cancer: Long\u2010term survival and factors associated with treatment refusal"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-7828","authenticated-orcid":false,"given":"Shayan","family":"Cheraghlou","sequence":"first","affiliation":[{"name":"Division of Otolaryngology Department of Surgery, Yale School of Medicine New Haven Connecticut U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery, Yale School of Medicine New Haven Connecticut U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saral","family":"Mehra","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery, Yale School of Medicine New Haven Connecticut U.S.A."},{"name":"Yale Cancer Center New Haven Connecticut U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendell G.","family":"Yarbrough","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery, Yale School of Medicine New Haven Connecticut U.S.A."},{"name":"Department of Pathology Yale School of Medicine New Haven CT U.S.A."},{"name":"Yale Cancer Center New Haven Connecticut U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-4220","authenticated-orcid":false,"given":"Benjamin L.","family":"Judson","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Department of Surgery, Yale School of Medicine New Haven Connecticut U.S.A."},{"name":"Yale Cancer Center New Haven Connecticut U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.01.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_6_4_1","volume-title":"Cancer Facts & Figures 2016","author":"American Cancer Society","year":"2016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2015.03.006"},{"key":"e_1_2_6_6_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Head and Neck Cancers (Version I.2016). 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