{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:12:39Z","timestamp":1770451959936,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Acta Otolaryngologica Foundation"},{"name":"ALF from Stockholm County Council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our previous randomized controlled trial of patients with obstructive sleep apnea syndrome (OSAS) showed that modified uvulopalatopharyngoplasty (UPPP), including tonsillectomy, significantly improved nocturnal respiration, daytime sleepiness, and quality of life in the intervention group compared to controls who had delayed surgery after 6 months. This is the continuous report with the 6\u2010 and 24\u2010month postoperative results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Single\u2010center prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010five patients with apnea\u2013hypopnea index (AHI) \u2265 15, body mass index (BMI) &lt; 36, Epworth Sleepiness Scale (ESS) \u2265 8, and Friedman stage I or II underwent UPPP after failing nonsurgical treatment. The results from polysomnography and ESS at 6 and 24 months were compared to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight percent and 20% dropped out from the 6\u2010 and 24\u2010month follow\u2010ups, respectively. The AHI value decreased significantly from mean (standard deviation) 52.9 (20.5) at baseline to 23.6 (20.2) after 6 months, and to 24.1 (20.9) after 24 months (<jats:italic>P<\/jats:italic> &lt; 0.001). Patients with tonsil size 2, and 3 to 4, had significant reductions in the AHI after both follow\u2010ups. The median ESS score decreased significantly from 13 (range 8\u201321) to 6.5 (1\u201318) after 6 months, and to 5 (2\u201317) after 24 months (<jats:italic>P<\/jats:italic> &lt; 0.001). The BMI remained unchanged. There were significant modest correlations for the reductions in AHI and ESS after 24 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Modified UPPP was effective in improving nocturnal respiration and daytime sleepiness in OSAS patients at both 6\u2010 and 24\u2010month follow\u2010up. Patients with tonsil size 2, and 3 to 4, benefitted similarly from surgery with improved respiration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 128:1238\u20131244, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26835","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T10:52:38Z","timestamp":1504263158000},"page":"1238-1244","source":"Crossref","is-referenced-by-count":22,"title":["SKUP<sup>3<\/sup>: 6 and 24 months follow\u2010up of changes in respiration and sleepiness after modified UPPP"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-1896","authenticated-orcid":false,"given":"Nanna","family":"Browaldh","sequence":"first","affiliation":[{"name":"Division of ENT Diseases Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet Stockholm Sweden"},{"name":"Department of ENT Diseases Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Bring","sequence":"additional","affiliation":[{"name":"Statisticon AB Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Friberg","sequence":"additional","affiliation":[{"name":"Division of ENT Diseases Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet Stockholm Sweden"},{"name":"Department of ENT Diseases Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00043-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25642"},{"key":"e_1_2_6_4_1","first-page":"1071","article-title":"Sleep disordered breathing and mortality: eighteen\u2010year follow\u2010up of the 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