{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:56:58Z","timestamp":1789649818107,"version":"4.0.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T00:00:00Z","timestamp":1507420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>The fibrotic\/erythematous appearance of the subglottis in idiopathic subglottic stenosis (iSGS) hints that it might respond to repeated intralesional steroid treatment similar to keloids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen iSGS subjects (six treated in\u2010office with serial intralesional steroid injections [SILSI] versus seven treated endoscopically in the operating room [OR] followed by awake SILSI) between October 2011 and April 2017. Forced spirometry was performed before injections and at each follow\u2010up visit (peak expiratory flow [%PEF] and peak inspiratory flow). Steroids were injected via transcricothyroid or transnasal routes. Injections were grouped into rounds of four to six injections separated by 3 to 5 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen subjects with a mean follow\u2010up of 3 years (3.3 years for SILSI and 2.7 years for OR). Awake\u2010only SILSI subjects had a mean improvement\/round of 23.1% %PEF (range, 65.4%\u201388.6%), whereas the OR\u2010treated subjects had a mean %PEF improvement\/round of 25.1% (range, 57.4%\u201382.5%). Both groups had improved breathing, and the improvements were statistically equal (<jats:italic>P<\/jats:italic>\u2009=\u2009.569). SILSI subjects underwent 5.3 injections\/round in 1.3 rounds, whereas OR subjects had 5.9 injections\/round over 2.1 rounds. Statistically significant improvement was seen in %PEF for both groups (SILSI <jats:italic>P<\/jats:italic>\u2009=\u2009.007, OR <jats:italic>P<\/jats:italic>\u2009=\u2009.002). Overall, SILSI achieved sustained %PEF above 80% in 83% (5\/6) and OR\u2009+\u2009SILSI 86% (6\/7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SILSI in the awake outpatient setting can improve the airway caliber in iSGS and is equivalent to endoscopic OR treatment. We believe iSGS can be viewed as a chronic scarring\/inflammatory condition that can benefit from steroid scar\u2010modification therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 128:610\u2013617, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26874","type":"journal-article","created":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T05:02:41Z","timestamp":1507438961000},"page":"610-617","source":"Crossref","is-referenced-by-count":93,"title":["Awake serial intralesional steroid injections without surgery as a novel targeted treatment for idiopathic subglottic stenosis"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-6017","authenticated-orcid":false,"suffix":"Jr.","given":"Ramon A.","family":"Franco","sequence":"first","affiliation":[{"name":"Division of Laryngology, Department of Otolaryngology Harvard Medical School and Massachusetts Eye and Ear Infirmary Boston Massachusetts U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Rush University Medical Center Chicago Illinois U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Reder","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Southern California Los Angeles California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Paddle","sequence":"additional","affiliation":[{"name":"Monash Health and Alfred Health Victoria Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2002.11.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700202"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24641"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22181"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.09.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199502000-00030"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199410000-00007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.11.022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-006-0253-y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(07)80045-X"},{"key":"e_1_2_7_14_1","first-page":"162","article-title":"Evaluation of cynthaskin and topical steroid in the treatment of hypertrophic scars and keloids","volume":"19","author":"Yii NW","year":"1996","journal-title":"Eur J Plast Surg"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002660010038"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00031"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:38:44Z","timestamp":1695713924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.26874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,8]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/lary.26874"],"URL":"https:\/\/doi.org\/10.1002\/lary.26874","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,8]]}}}