{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:17:39Z","timestamp":1768616259588,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To assess the performance of endoscopic grading systems of glossoptosis in identifying severe clinical manifestations in children with Robin sequence (RS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Nested cohort cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All RS patients diagnosed at Hospital Clinics of Porto Alegre from October 2012 to June 2016 were enrolled in this cohort. Patients underwent sleep endoscopy and were classified according to Yellon (Y) and de Sousa et al. (S) scales. Symptom severity evaluation was performed as defined by Cole et al. The outcome of interest was Cole's clinical classification grade 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty patients were eligible for analysis. Sensitivity (Y: 56.2%, S: 28.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and specificity (Y: 85.4%, S: 93.8%, <jats:italic>P<\/jats:italic>\u2009=\u2009.038) in identifying severe clinical symptoms patients (i.e., Cole grade 3) were statistically different between Y and S classifications. A low but significant overall correlation was observed for both Y (rho\u2009=\u20090.372, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and S (rho\u2009=\u20090.439, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) classifications when compared with Cole classification. Diagnostic odds ratio (DOR) for Y (DOR: 7.53, 95% confidence interval [CI]: 4.15\u201010.90) and S (DOR: 5.87, 95% CI: 1.86\u20109.87) were equivalent (<jats:italic>P<\/jats:italic>\u2009=\u2009.92). Also, receiver operating characteristic curves area under the curve were not significantly different between them. The positive likelihood ratio was 3.86 (95% CI: 1.82\u20108.16) and 4.50 (95% CI: 1.32\u201015.36) for Y and S, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Y and S grading systems showed a low sensitivity and moderate to high specificity in detecting patients with severe clinical manifestations. Correlation between Y\/S and Cole et al. grading were also considered low. Development of a more discriminative anatomic grading system is still needed for this specific disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2b. <jats:italic>Laryngoscope<\/jats:italic>, 128:502\u2013508, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26882","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T04:32:46Z","timestamp":1505968366000},"page":"502-508","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic accuracy of current glossoptosis classification systems: A nested cohort cross\u2010sectional study"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2438-3355","authenticated-orcid":false,"given":"Denise","family":"Manica","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade da Crian\u00e7a e do Adolescente Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Schweiger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade da Crian\u00e7a e do Adolescente Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Sekine","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Epidemiologia Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Chaves","family":"Fagondes","sequence":"additional","affiliation":[{"name":"Department of Pulmonology Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Kuhl","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Vinicius Collares","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Jos\u00e9 Cauduro","family":"Marostica","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade da Crian\u00e7a e do Adolescente Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.0796"},{"key":"e_1_2_6_3_1","first-page":"541","article-title":"Glossoptosis due to atresia and hypotrophy of the mandible","volume":"48","author":"Robin P","year":"1934","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.6.1751557"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182865da0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3181f6f618"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200410000-00026"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.11.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000191562.67363.e5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1597\/02-044"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2016.09.036"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1597\/08-061.1"},{"key":"e_1_2_6_13_1","first-page":"37","article-title":"La chute de la base de la langue consid\u00e9r\u00e9e comme une nouvelle cause de g\u00e9ne dans la respiration naso\u2010pharyngienne","author":"Robin P","year":"1923","journal-title":"Bull Acad Natl Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31374"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2615"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1597\/07-129.1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00177-X"},{"key":"e_1_2_6_18_1","unstructured":"SchwartzA.Diagnostic test calculator version 2010042101. Available at:http:\/\/araw.mede.uic.edu\/cgi-bin\/testcalc.pl. Last access on 10th November 2016."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2015.01.035"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569(1992)029<0224:MOAOIR>2.3.CO;2"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1136\/bmj.323.7322.1188a","article-title":"Systematic reviews of evaluations of diagnostic and screening tests. Odds ratio is not independent of prevalence","volume":"323","author":"Blackman NJ","year":"2001","journal-title":"BMJ"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T23:39:38Z","timestamp":1695857978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.26882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,20]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/lary.26882"],"URL":"https:\/\/doi.org\/10.1002\/lary.26882","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,20]]}}}