{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:43:18Z","timestamp":1782398598003,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010479","name":"Cook Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Vocal fold scar is a major cause of dysphonia, and optimal treatments do not currently exist. Small intestinal submucosa (SIS) is a biomaterial developed for the treatment of a variety of pathologies. The purpose of this study was to investigate the effects of SIS implantation on tissue remodeling in scarred vocal folds using routine staining, immunohistochemistry, and high\u2010speed videoendoscopy (HSV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, blinded group analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen New Zealand White rabbits underwent a vocal fold scarring procedure followed by microflap elevation with or without SIS implantation. Seven months later, they underwent a phonation procedure with HSV and laryngeal harvest. Alcian blue and elastica van Gieson staining and immunohistochemistry for collagen types I and III were used to evaluate histological healing outcomes. Dynamic functional remodeling of the scarred vocal fold in the presence of SIS implants was evaluated using HSV imaging to capture restoration of vibratory amplitude, amplitude ratio, and left\u2010right phase symmetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Density of collagen I was significantly decreased in SIS versus microflap\u2010treated vocal folds. No differences were found between groups for hyaluronic acid, elastin, or collagen type III. Organization of elastin in the subepithelial region appeared to affect amplitude of vibration and the shape of the vocal fold edge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SIS implantation into chronic scar reduced the density of collagen I deposits. There was no evidence of a negative impact or complication from SIS implantation. Regardless of treatment type, organization of elastin in the subepithelial region may be important to vibratory outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA. <jats:italic>Laryngoscope<\/jats:italic>, 128:901\u2013908, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26883","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T06:13:06Z","timestamp":1509948786000},"page":"901-908","source":"Crossref","is-referenced-by-count":25,"title":["Vibratory function and healing outcomes after small intestinal submucosa biomaterial implantation for chronic vocal fold scar"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-4302","authenticated-orcid":false,"given":"Michael J.","family":"Pitman","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Voice and Swallowing Institute Columbia University Medical Center\/New York Presbyterian New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Vanderbilt University Medical Center Nashville Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Vanderbilt University Medical Center Nashville Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Kimball","sequence":"additional","affiliation":[{"name":"Department of Hearing and Speech Sciences Vanderbilt University Medical Center Nashville Tennessee U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Corning Research and Development Corporation Painted Post New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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