{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:01:53Z","timestamp":1791331313783,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>To assess the differences between patients with laryngeal squamous cell carcinoma under 40 years old and those 40 years old or older. A secondary objective was to compare survival outcome between these cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical charts of all patients treated in our tertiary referral center for laryngeal squamous cell carcinoma from 2005 to 2014. Patients aged\u2009&lt;\u200940 years at diagnosis were compared to older patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group comprised 160 patients. Of them, 13 were aged\u2009&lt;\u200940 years at diagnosis. Mean age was 35\u2009\u00b1\u20093.9 years and 64.4\u2009\u00b1\u200911 years for the two groups. Among the younger patients, 38% were smokers (mean pack\/day, 2.2) versus 71% in the older group (mean pack\/day, 3). The younger group typically had a more advanced stage than the older group at presentation; eight young patients (62%) had stage III or IV versus 49 (33%) in the older group (<jats:italic>P<\/jats:italic>\u2009=\u2009.042). Mean overall survival was 6.7\u2009\u00b1\u20091 years for those under 40 years old and 7.7\u2009\u00b1\u20090.2 years for the older patients (<jats:italic>P<\/jats:italic>\u2009=\u2009.2). The 5\u2010year survival rate was 69% for young patients and 90% for the older group (<jats:italic>P<\/jats:italic>\u2009=\u2009.04). However, there was no significant between\u2010group difference in overall survival or 5\u2010year survival rate when stratified for early\u2010 and late\u2010stage disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a lower prevalence of classic risk factors in younger patient with laryngeal carcinoma in this study, suggesting a different etiology compared to our older cohort. The under\u201040 cohort presented with more advanced disease and had a worse 5\u2010year survival; however, when stratified for early\u2010 versus late\u2010stage disease, there was no significant difference in overall or 5\u2010year survival between the groups. This may suggest that, despite a different etiology, laryngeal cancer behaves similarly in older and younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 128:1602\u20131605, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26951","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T10:41:47Z","timestamp":1509100907000},"page":"1602-1605","source":"Crossref","is-referenced-by-count":17,"title":["Assessment of laryngeal cancer in patients younger than 40 years"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-4647","authenticated-orcid":false,"given":"Yuval","family":"Nachalon","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Alkan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Shvero","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-1161","authenticated-orcid":false,"given":"Dan","family":"Yaniv","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotam","family":"Shkedy","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Limon","sequence":"additional","affiliation":[{"name":"Davidoff Cancer Center Rabin Medical Center\u2013Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Popovtzer","sequence":"additional","affiliation":[{"name":"Davidoff Cancer Center Rabin Medical Center\u2013Beilinson Hospital Petach Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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