{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:24:17Z","timestamp":1760217857455,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["RO1 DC013277"],"award-info":[{"award-number":["RO1 DC013277"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Although the primary goal of medialization laryngoplasty is to improve glottic closure, implant placement is also likely to alter the biomechanical properties of the vocal fold (VF). We sought to employ novel, nanoscale technology to quantify these properties following medialization based on the hypothesis that different medialization materials will likely yield differential biomechanical effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Ex vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine pig larynges were divided into three groups: control, Silastic (Dow Corning, Midland, Michigan, U.S.A.) block medialization, or Gore\u2010Tex (W.L. Gore &amp; Associates, Newark, Delaware) medialization. Laryngoplasty was performed on excised, intact larynges. The larynges were then bisected in the sagittal plane and each subjected to dynamic nanomechanical analysis (nano\u2010DMA) at nine locations using a 250\u2010\u03bcm flat\u2010tip punch and frequency sweep\u2010load profile across the free edge of the VF and inferiorly along the conus elasticus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Silastic block and Gore\u2010Tex implant introduced increased storage and loss moduli. Overall, storage moduli mean (maximum) increased from 38 kilopascals (kPa) (119) to 72 kPa (422) and 129 kPa (978) in control, Gore\u2010Tex, and Silastic implants, respectively. Similarly, loss moduli increased from 13 kPa (43) to 22 kPa (201) and 31 kPa (165), respectively. Moduli values varied widely by location in the Silastic block and Gore\u2010Tex groups. At the free VF edge, mean (maximum) storage moduli were lowest in the Gore\u2010Tex group, 20 kPa (44); compared to control, 34.5 kPa (86); and Silastic, 157.9 kPa (978), with similar loss and complex moduli trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Medialization laryngoplasty altered VF structure biomechanical properties; Silastic and Gore\u2010Tex implants differentially impact these properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA. <jats:italic>Laryngoscope<\/jats:italic>, 128:1163\u20131169, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26963","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T09:13:05Z","timestamp":1507540385000},"page":"1163-1169","source":"Crossref","is-referenced-by-count":9,"title":["Impact of medialization laryngoplasty on dynamic nanomechanical vocal fold structure properties"],"prefix":"10.1002","volume":"128","author":[{"given":"Gregory R.","family":"Dion","sequence":"first","affiliation":[{"name":"NYU Voice Center, Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Brooke Army Medical Center Fort Sam Houston Texas U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Benedict","sequence":"additional","affiliation":[{"name":"NYU Voice Center, Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo G.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomimetics New York University College of Dentistry New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan R.","family":"Amin","sequence":"additional","affiliation":[{"name":"NYU Voice Center, Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-9036","authenticated-orcid":false,"given":"Ryan C.","family":"Branski","sequence":"additional","affiliation":[{"name":"NYU Voice Center, Department of Otolaryngology\u2013Head and Neck Surgery New York University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25739"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000748"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(98)80028-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70025-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(00)80084-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000162644.63752.BC"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2012.07.011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2014.07.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26410"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.04.018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20031"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.08.051"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2009.09.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.12.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2012.0034"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2011.05.027"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1557\/jmr.2009.0130"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.20096"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2013.11.001"}],"container-title":["The 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