{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:07:53Z","timestamp":1771045673763,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Acclarent, Inc.","award":["IIS: A-007"],"award-info":[{"award-number":["IIS: A-007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Despite wide adoption of strategies to prevent injury from prolonged intubation and tracheotomy, acquired laryngotracheal stenosis (ALTS) has not disappeared. ALTS\u2019 persistence may be due to patient factors that confer unique susceptibility for some. We sought to identify genetic markers in genes associated with wound healing that could be associated with ALTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred thirty\u2010eight patients were recruited, 53 patients with ALTS and 85 control patients who underwent intubation or tracheotomy without evidence of ALTS. The patients\u2019 DNA was isolated from whole blood. Custom primers were designed, and the TaqMan assay employing allele\u2010specific polymerase chain reaction was used to interrogate single nucleotide polymorphisms (SNPs) rs1799750, rs522616, rs2276109, rs2569190, rs1800469, and rs1024611 of candidate wound healing genes <jats:italic>MMP1, MMP3, MMP12, CD14, TGF\u03b21<\/jats:italic>, and <jats:italic>MCP1<\/jats:italic>, respectively. A logistic regression model was used to examine the association of candidate gene polymorphisms with the presence or absence of ALTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 138 patients were successfully genotyped. No significant association was found between candidate SNPs and development of ALTS in the overall group. However, subgroup analysis within each ethnicity identified SNPs that are associated with ALTS depending upon the ethnic background.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient factors such as variations in wound healing due to functional SNPs may shed light on the development of ALTS. There may be a difference in susceptibility to developing ALTS in different ethnic backgrounds. These preliminary findings need to be corroborated in larger population studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>3b. <jats:italic>Laryngoscope<\/jats:italic>, 128:E111\u2013E116, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26981","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T05:03:23Z","timestamp":1511327003000},"source":"Crossref","is-referenced-by-count":10,"title":["Determining Candidate Single Nucleotide Polymorphisms in Acquired Laryngotracheal Stenosis"],"prefix":"10.1002","volume":"128","author":[{"given":"Mursalin M.","family":"Anis","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Lewis Katz School of Medicine at Temple University Philadelphia Pennsylvania"},{"name":"Coastal Ear, Nose and Throat Neptune New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Krynetskaia","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Temple University School of Pharmacy Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Statistics Fox School of Business, Temple University Philadelphia Pennsylvania U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny","family":"Krynetskiy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Temple University School of Pharmacy Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-2944","authenticated-orcid":false,"given":"Ahmed M. S.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Lewis Katz School of Medicine at Temple University Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-3359(03)00034-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2009.175"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940711600308"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/3.2.146"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.11.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.1.93"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24382"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0581"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.06.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2008.00552.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200206000-00017"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414521382"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.012062"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2009.03.008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100237"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008881"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057958"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1472-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-2-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22364"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/521754"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-63"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25708"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181648d4a"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26097"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)80033-1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903539"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45666"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535496"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.26981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.26981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:38:18Z","timestamp":1695713898000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.26981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/lary.26981"],"URL":"https:\/\/doi.org\/10.1002\/lary.26981","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,22]]}}}