{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:31:41Z","timestamp":1783467101110,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objectives\/Hypothesis<\/jats:title><jats:p>Eosinophils and mast cells are among the key cells in inflammatory diseases like chronic rhinosinusitis (CRS) and asthma. Leukotriene antagonists have proven to be effective in the treatment of asthma, but data about their efficacy in CRS are scarce, whereas data on montelukast as an add\u2010on treatment to intranasal corticosteroids (INCS) in a postoperative setting are completely lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, randomized, open\u2010label trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this trial with long\u2010term follow\u2010up, we evaluated the efficacy of montelukast as an add\u2010on treatment to INCS in postoperative CRS with nasal polyp (CRSwNP) patients. CRSwNP patients (N = 72) undergoing endoscopic sinus surgery were randomized in two arms for the postoperative treatment. One group (N = 36) received INCS in monotherapy, whereas the other group (N = 36) received INCS in association with montelukast for 1 year. The efficacy of montelukast with INCS was evaluated by assessing both subjective (total five\u2010symptom score [T5SS]) and objective (nasal polyp score [NPS], Lund\u2010Mackay [LMK] score, and subjective olfactometry [Barcelona Smell Test 24]) outcome parameters and compared with the gold standard of INCS in monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 1 year of surgery, T5SS, NPS, and LMK score were significantly reduced in patients treated with either INCS or INCS plus montelukast, without significant differences between the two treatment arms. Improvement of smell loss by olfactometry was also observed with no differences between arms. Similar findings were observed at 3 and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that the addition of montelukast to INCS should not be recommended in the treatment of postoperative CRSwNP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>1b <jats:italic>Laryngoscope<\/jats:italic>, 1743\u20131751, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.26989","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:48:20Z","timestamp":1510130900000},"page":"1743-1751","source":"Crossref","is-referenced-by-count":24,"title":["Lack of long\u2010term add\u2010on effect by montelukast in postoperative chronic rhinosinusitis patients with nasal polyps"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5325-7956","authenticated-orcid":false,"given":"Laura","family":"Van Gerven","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Rhinology and Skull Base Unit, Hospital Clinic University of Barcelona Barcelona Spain"},{"name":"Clinical Division of Otorhinolaryngology, Head and Neck Surgery University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Langdon","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Rhinology and Skull Base Unit, Hospital Clinic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Cordero","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Rhinology and Skull Base Unit, Hospital Clinic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cardel\u00fas","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Rhinology and Skull Base Unit, Hospital Clinic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Rhinology and Skull Base Unit, Hospital Clinic University of Barcelona Barcelona Spain"},{"name":"ENT Department, Rhinology Unit and Smell Clinic, Clinical and Experimental Respiratory Immunoallergy, The August Pi i Sunyer Biomedical Research Institute Center for Biomedical Research in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-5599","authenticated-orcid":false,"given":"Isam","family":"Alobid","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Rhinology and Skull Base Unit, Hospital Clinic University of Barcelona Barcelona Spain"},{"name":"ENT Department, Rhinology Unit and Smell Clinic, Clinical and Experimental Respiratory Immunoallergy, The August Pi i Sunyer Biomedical Research Institute Center for Biomedical Research in Respiratory Diseases Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"e_1_2_6_3_1","first-page":"3","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"key":"e_1_2_6_4_1","first-page":"131","article-title":"Comparison of radical (nasalisation) and functional ethmoidectomy in patients with severe sinonasal polyposis. A retrospective study","volume":"127","author":"Jankowski R","year":"2006","journal-title":"Rev Laryngol Otol Rhinol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1233-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26391"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816640723"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_6_9_1","unstructured":"Global Initiative for Asthma.2017 GINA report: global strategy for asthma management and prevention. Available at:http:\/\/ginasthma.org\/2017\u2010gina\u2010report\u2010global\u2010strategy\u2010for\u2010asthma\u2010management\u2010and\u2010prevention. 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