{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:45:22Z","timestamp":1778834722317,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI)","award":["HI13C1501"],"award-info":[{"award-number":["HI13C1501"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green\u2010neomannosyl human serum albumin (ICG:MSA) and a custom\u2010made intraoperative color\u2010and\u2010fluorescence\u2010merged imaging system (ICFIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using mouse and rabbit models of tongue cancer, we performed sentinel lymph node biopsy using an ICG:MSA tracer and custom imaging system equipped with an endoscope.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ICG:MSA was localized to the cervical lymph node on the ipsilateral side for up to 30 minutes compared to ICG tracer (ICG n\u2009=\u20093, IGC:MSA n\u2009=\u20093). Detection of sentinel lymph nodes was attempted after injecting ICG:MSA in the mouse tongue cancer model (n\u2009=\u20093). During the operation, lymph nodes were easily identified and resected using ICFIS without the aid of other magnifiers. In the rabbit tongue cancer model (n\u2009=\u20093), the ICFIS equipped with 30\u2010degree endoscopy was used to confirm the feasibility of endoscopic sentinel lymph node biopsy. The entire sentinel lymph node biopsy procedure was performed using the ICFIS with the 30\u2010degree endoscope. We detected and dissected sentinel lymph nodes in the rabbit model without the other sentinel lymph node detection tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We confirmed the usefulness of sentinel lymph node biopsy using a near infrared fluorescence technique and endoscopic system. Avoidance of radiation exposure and shine\u2010through phenomena, which are problems of sentinel lymph node biopsy using conventional radioisotopes, are advantages of our surgical technique. By combining the endoscopic system with a sentinel lymph node biopsy procedure, we avoided visible neck scars, which lead to excellent cosmetic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA. <jats:italic>Laryngoscope<\/jats:italic>, 128:E135\u2013E140, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27036","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T07:28:51Z","timestamp":1512631731000},"source":"Crossref","is-referenced-by-count":8,"title":["Endoscopic sentinel lymph node biopsy using indocyanine green\u2010neomannosyl human serum albumin"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-8461","authenticated-orcid":false,"given":"Young Min","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hua","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Korea University College of Medicine Seoul Republic of Korea"},{"name":"Department of Biomedical Sciences, College of Medicine Korea University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hyeok","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Bio\/Micro System Technology Korea University College of Engineering Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Gu","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-0976","authenticated-orcid":false,"given":"Jeong\u2010Soo","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beop\u2010Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Bio\/Micro System Technology Korea University College of Engineering Seoul Republic of Korea"},{"name":"Department of Bio\u2010convergence Engineering, School of Biomedical Engineering Korea University College of Health Science Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun\u2010Sang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Min","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Koo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Korea University College of Medicine Seoul Republic of Korea"},{"name":"Department of Biomedical Sciences, College of Medicine Korea University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Seoul Republic of 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