{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:55:56Z","timestamp":1768888556752,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the incidence and determinants of survival of patients with squamous cell carcinoma of the hard palate (SCCHP) between the years of 1973 to 2014 using the Surveillance, Epidemiology, and End Results (SEER) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective, population\u2010based cohort study of patients in the SEER tumor registry who were diagnosed with SCCHP from 1973 to 2014. Outcomes and measures included overall survival (OS) and disease\u2010specific survival (DSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,489 cases of primary SCCHP were identified. Of those, 53.2% were females and 47.8% presented with stage IV disease. The mean age at diagnosis was 69.8 years. Overall survival at 2, 5, and 10 years was 44%, 33%, and 21%, respectively. A total of 66.2% of patients underwent surgery (with or without radiation therapy [RT]); 20.1% received RT; and 22.4% had both surgical and RT. On multivariate analysis, RT, advanced age, stage, and grade were associated with worse OS and DSS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Surgical therapy (with or without radiation) was an independent favorable predictor of OS and DSS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SCCHP is relatively infrequent tumor that portends an overall poor prognosis when advanced stage and a greater prognosis when early stage. Surgical therapy was found to be an independent predictor for improved OS and DSS, whereas RT was associated with reduced OS and DSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 128:2050\u20132055, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27080","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T05:06:39Z","timestamp":1517807199000},"page":"2050-2055","source":"Crossref","is-referenced-by-count":11,"title":["The survival impact of surgical therapy in squamous cell carcinoma of the hard palate"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-7347","authenticated-orcid":false,"given":"Jose E.","family":"Alonso","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at UCLA Los Angeles California U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-6634","authenticated-orcid":false,"given":"Albert Y.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at UCLA Los Angeles California U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0718","authenticated-orcid":false,"given":"Edward C.","family":"Kuan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at UCLA Los Angeles California U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Strohl","sequence":"additional","affiliation":[{"name":"UCSF Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon Mallen\u2010St.","family":"Clair","sequence":"additional","affiliation":[{"name":"UCSF Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maie A.","family":"St. John","sequence":"additional","affiliation":[{"name":"UCSF Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery San Francisco"},{"name":"Jonsson Comprehensive Cancer Center Los Angeles California U.S.A"},{"name":"UCLA Head and Neck Cancer Program Ronald Reagan UCLA Medical Center Los Angeles California U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Ryan","sequence":"additional","affiliation":[{"name":"UCSF Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chase M.","family":"Heaton","sequence":"additional","affiliation":[{"name":"UCSF Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology\u2013Head and Neck Surgery San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/82.7.878"},{"key":"e_1_2_6_3_1","volume-title":"Cancer Facts & Figures 2017","author":"American Cancer Society","year":"2017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24079"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200001)22:1<17::AID-HED4>3.0.CO;2-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21547"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.07.012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20054"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.12.017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.2846"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.3455"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24302"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24511"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24542"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24679"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.11.015"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21547"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000233607.41540.28"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.09.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00136-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24274"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flary.27080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lary.27080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:40:31Z","timestamp":1694688031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lary.27080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/lary.27080"],"URL":"https:\/\/doi.org\/10.1002\/lary.27080","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]}}}