{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:08:36Z","timestamp":1791821316281,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","award":["HY\u20102017"],"award-info":[{"award-number":["HY\u20102017"]}],"id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","award":["201700000000486"],"award-info":[{"award-number":["201700000000486"]}],"id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical significance of 4\u2010hour delayed\u2010enhanced 3.0 Tesla three\u2010dimensional (3D) fluid\u2010attenuated inversion recovery (FLAIR) magnetic resonance (MR) imaging in acute vestibular neuritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010nine vestibular neuritis patients were enrolled between January 2017 and June 2017. Vestibular function tests, comprising the caloric and video head impulse tests and vestibular\u2010evoked myogenic potential measurements, were performed. Precontrast, 10\u2010minute, and 4\u2010hour delayed\u2010enhanced 3D\u2010FLAIR MR images using double\u2010dose IV gadolinium were obtained. After laterality and extent of inner ear enhancement were defined, the patients were divided into groups based on the patterns of enhancement, and clinical parameters were analyzed according to the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients (20 of 29, 69.0%) had obviously asymmetric enhancement of the affected inner ear structures on 4\u2010hour delayed images, whereas only three patients (10.3%) had marked enhancement on 10\u2010minute delayed images. The duration of spontaneous nystagmus (DurSN) was significantly longer in the patients with enhancement, especially with enhancement of the whole inner ear, including the vestibule and semicircular canals (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.033). Spontaneous nystagmus resolved within 12 days in patients without laterality of enhancement, and within 16 days in ipsilesional enhancement confined to the inner auditory canal and fundus. Other results of vestibular function tests did not reveal any significant associations with MR enhancement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contrast enhancement of the vestibular nerve and inner ear structures can be identified on 4\u2010hour delayed\u2010enhanced 3T 3D\u2010FLAIR MR images in acute vestibular neuritis. The extent of inner ear enhancement may be associated with the DurSN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 1946\u20131951, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27084","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T13:46:39Z","timestamp":1515851199000},"page":"1946-1951","source":"Crossref","is-referenced-by-count":42,"title":["Clinical value of 4\u2010hour delayed gadolinium\u2010Enhanced 3D FLAIR MR Images in Acute Vestibular Neuritis"],"prefix":"10.1002","volume":"128","author":[{"given":"Hayoung","family":"Byun","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-7927","authenticated-orcid":false,"given":"Jae Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology College of Medicine, Hanyang University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology College of Medicine, Hanyang University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1354598"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2015.04.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/459048"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25204"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001352"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509121922"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.171.3.2717756"},{"key":"e_1_2_6_9_1","first-page":"735","article-title":"Contrast\u2010enhanced MR imaging of the facial nerve in 11 patients with Bell's palsy","volume":"11","author":"Tien R","year":"1990","journal-title":"AJNR Am J 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