{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:22:34Z","timestamp":1792678954775,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>During monitored thyroidectomy, displacement of the recurrent laryngeal nerve (RLN) or vagus nerve (VN) in some complicated cases can increase the risk of injury. Although increasing the stimulus current can facilitate nerve mapping and localization, the safety of a high\u2010current stimulus remains unknown. Therefore, this study evaluated the safety of a high\u2010current stimulus in a porcine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Short\u2010duration (1 minute), high\u2010current (3, 5, 10, 15, 20, 25, and 30 mA at 4Hz) stimulus pulses were repeatedly applied to the RLN or VN in six anesthetized piglets. The safety of the high\u2010current stimulus pulses was assessed in terms of hemodynamic stability during VN stimulation and in terms of nerve function integrity after VN and RLN stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During VN stimulation with a high\u2010current stimulus pulse, sinus rhythms in all six piglets showed stable heart rates, and mean arterial pressure was unaffected. High\u2010current stimulation of the VN and the RLN did not affect electromyography amplitude or latency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This porcine study showed that applying a short\u2010duration, high\u2010current stimulus pulse to the VN or RLN during monitored thyroidectomy has no harmful effects. In clinical practice, a short duration of high\u2010current stimulus can be applied to facilitate neural mapping, especially in patients with disoriented nerve positions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA. <jats:italic>Laryngoscope<\/jats:italic>, 128:2206\u20132212, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27086","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T13:46:45Z","timestamp":1515851205000},"page":"2206-2212","source":"Crossref","is-referenced-by-count":10,"title":["Safety of high\u2010current stimulation for intermittent intraoperative neural monitoring in thyroid surgery: A porcine model"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-1071","authenticated-orcid":false,"given":"I\u2010Cheng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Kaohsiung Taiwan"},{"name":"Faculty of Medicine, College of 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