{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:53:16Z","timestamp":1780084396824,"version":"3.54.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004370","name":"Tampereen Teknillinen Yliopisto","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100004370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Treatment for laryngopharyngeal reflux disease (LPRD) is challenging because of delays in recognition and poor responsiveness to proton\u2010pump inhibitor therapy. The aim of this study was to determine the efficacy and safety of liquid alginate suspension for treating LPRD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, placebo\u2010controlled, prospective study comparing 8 weeks of treatment with Alginos Oral Suspension (TTY Biopharm Co. Ltd., Taipei, Taiwan) (sodium alginate 1,000\u2009mg three times daily) with a placebo was conducted on patients who fulfilled the criteria of at least one symptom consistent with LPRD, a total reflux symptom index (RSI) score of\u2009&gt;\u200910, and a total reflux finding score (RFS) of\u2009&gt;\u20095. Those with erosive gastroesophageal reflux disease, as evidenced through screened transnasal upper gastrointestinal endoscopy, were excluded. Efficacy was assessed by RSI, RFS, and ambulatory multichannel intraluminal impedance and pH (MII\u2010pH) monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 80 patients aged 22 to 72 years were enrolled. Compared with baseline, both Alginos (TTY Biopharm Co. Ltd.) and the placebo significantly reduced the total RSI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and the total number of reflux episodes shown by MII\u2010pH monitoring (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) after 8 weeks of treatment. However, liquid alginate suspension was unable to show superiority over the placebo. The incidence of various adverse events from Alginos (TTY Biopharm Co. Ltd.) was relatively low (7.7%) and mild.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that liquid alginate suspension was well tolerated by LPRD patients. It effectively improved symptoms and reflux numbers but was unable to show superiority over placebo. As observed in previous studies, a great placebo effect was present. The importance of lifestyle modification could not be overlooked.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>2. <jats:italic>Laryngoscope<\/jats:italic>, 128:2252\u20132260, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27111","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T05:06:38Z","timestamp":1517807198000},"page":"2252-2260","source":"Crossref","is-referenced-by-count":37,"title":["Double\u2010blind, placebo\u2010controlled study with alginate suspension for laryngopharyngeal reflux disease"],"prefix":"10.1002","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-4637","authenticated-orcid":false,"given":"Wen\u2010Hsuan","family":"Tseng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, College of Medicine National Taiwan University and National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Huei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Chin","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine National Taiwan University and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine National Taiwan University and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Hsuan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Yu","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine National Taiwan University and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Chung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine National Taiwan University and National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/S1542-3565(03)00177-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000193177.62074.fd"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-016-0486-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.12.1534"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2.5.665"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.2.157"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112728"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/MCG.0b013e31802b64f3","article-title":"Use of pH\u2010impedance testing to evaluate patients with suspected extraesophageal manifestations of gastroesophageal reflux disease","volume":"42","author":"Malhotra A","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2581461"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dow020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.15403\/jgld.2014.1121.254.dea","article-title":"Mucosal protective compounds in the treatment of gastroesophageal reflux disease. 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