{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:47:14Z","timestamp":1778572034508,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630023"],"award-info":[{"award-number":["81630023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100704"],"award-info":[{"award-number":["81100704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81441029"],"award-info":[{"award-number":["81441029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81441031"],"award-info":[{"award-number":["81441031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570894"],"award-info":[{"award-number":["81570894"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400444"],"award-info":[{"award-number":["81400444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470678"],"award-info":[{"award-number":["81470678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Although local specific immunoglobulin (sIgE) has been employed as a diagnostic criterion for allergic rhinitis (AR), the use of local sIgE has not been fully evaluated in the diagnosis of allergic rhinitis. The aim of this study was to evaluate the use of nasal secretion sIgE in the diagnosis of allergic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 51 patients (27 males and 24 females, mean age\u2009=\u200933.3 years) with rhinitis symptoms were enrolled consecutively from the allergy\u2010rhinology clinic of Beijing TongRen Hospital (Beijing, People's Republic of China). Questionnaires were completed by each participant at recruitment to record demographic data, nasal symptom severity, and physician\u2010diagnosed comorbid asthma. The severity of nasal obstruction, rhinorrhea, sneezing, and nasal\/eye itching was recorded according to a visual analogue scale (VAS) of 10\u2009cm. Sensitization to <jats:italic>Dermatophagoides pteronyssinus, Dermatophagoides farinae<\/jats:italic>, mugwort, <jats:italic>Candida albicans, Penicillium notatum, Alternaria, Cladosporium<\/jats:italic>, and <jats:italic>Aspergillus<\/jats:italic> were assessed according to presence of sIgE antibodies to these allergens in serum and nasal secretions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VAS scores of the participants ranged from 11 to 25 (mean\u2009=\u200917), and 14 (27.5%) patients had comorbid asthma. Based on serum sIgE, 31 (60.8%) patients were allergic to mugwort, 14 (27.5%) to <jats:italic>Dermatophagoides<\/jats:italic>, and three (5.9%) to fungal allergens. Based on nasal secretion sIgE, 32 (62.7%) patients were allergic to mugwort, 12 (23.5%) to <jats:italic>Dermatophagoides<\/jats:italic>, and three (5.9%) to fungal allergens. The local mugwort sIgE level and serum mugwort sIgE level were positively correlated with each other and with VAS scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>sIgE level in nasal secretions of subjects with rhinitis is a reliable noninvasive alternative to serum sIgE for diagnosis of allergic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 128:E311\u2013E315, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27120","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T07:06:46Z","timestamp":1518073606000},"source":"Crossref","is-referenced-by-count":15,"title":["The use of specific immunoglobulin <scp>E<\/scp> in nasal secretions for the diagnosis of allergic rhinitis"],"prefix":"10.1002","volume":"128","author":[{"given":"Yifan","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing People's Republic of China"},{"name":"Department of Allergy Beijing TongRen Hospital, Capital Medical University Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengshuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing People's Republic of 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