{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:24:44Z","timestamp":1790645084312,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The utility of fluorodeoxyglucose positron emission tomography (FDG\u2010PET) imaging to predict outcome has been well\u2010established for patients undergoing definitive radiation in the initial management of head and neck cancer. However, the usefulness of this modality in the recurrent setting remains uncertain. We sought to evaluate the prognostic value of metabolic tumor parameters measured on FDG\u2010PET in patients treated by reirradiation for recurrent head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four tumors occurring in 29 patients were reirradiated and were evaluable. The most common disease sites were the oropharynx (n\u2009=\u20099), oral cavity (N\u2009=\u20098), and nasopharynx (n\u2009=\u20096). Potential correlations of FDG\u2010PET maximum standardized uptake value (SUV) and metabolic tumor volume (MTV) with survival endpoints were explored. Multivariate analysis was performed using Cox proportional hazard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median MTV, SUV, and gross tumor volume, as delineated using the 50% SUVmax threshold, were 366 cc (range, 0\u20133,567 cc), 8.1 (range, 0\u201325), and 48.5 cc (range, 1\u2013190 cc), respectively. On univariate analysis, both MTVs (as measured as a continuous variable and using the median value of 266 cc as cutoff) were predictive of decreased overall survival (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for both). A strong trend toward decreased progression\u2010free survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.05), in\u2010field control (<jats:italic>P<\/jats:italic>\u2009=\u20090.06), and locoregional control (<jats:italic>P<\/jats:italic>\u2009=\u20090.07) was also observed with increasing MTV when analyzed as a continuous variable. Multi\u2010variate analysis confirmed MTV as an independent predictor of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The PET\u2010derived parameter MTV may serve as a potentially valuable factor for risk stratification and for guiding treatment in future reirradiation trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>4. <jats:italic>Laryngoscope<\/jats:italic>, 128:2345\u20132350, 2018<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.27173","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T11:12:56Z","timestamp":1521889976000},"page":"2345-2350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["FDG\u2010PET metabolic tumor parameters for the reirradiation of recurrent head and neck cancer"],"prefix":"10.1002","volume":"128","author":[{"given":"Maria A.","family":"Velez","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene","family":"Veruttipong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Chieh","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-5205","authenticated-orcid":false,"given":"Elliot","family":"Abemayor","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Kansas School of Medicine Kansas City Kansas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maie","family":"St. John","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Kansas School of Medicine Kansas City Kansas U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindi","family":"TenNapel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, Los Angeles, David Geffen School of Medicine Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-712X","authenticated-orcid":false,"given":"Allen M.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Los Angeles California"},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of California, Los Angeles, David Geffen School of Medicine Los Angeles 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